About this Research Topic
The field of Molecular Radiobiology, a multidisciplinary area intersecting radiation physics and biology, is fundamental to cancer management. The recent developments in this field have revolutionized oncology, ushering in the era of precision medicine. A significant area of progress is dosimetry, which involves the precise measurement and calculation of radiation doses delivered to tumors and surrounding healthy tissues. Techniques such as intensity-modulated radiation therapy (IMRT) and proton therapy have enabled clinicians to tailor radiation doses with unprecedented accuracy. Additionally, advances in molecular biology and genetics have facilitated the identification of biomarkers that predict a patient's response to radiation therapy, particularly to molecular radionuclide therapy (MRT). This personalized approach allows oncologists to optimize treatment plans, selecting the most effective radiation regimen for everyone. However, despite these advancements, there are still challenges to be addressed, such as understanding complex dose-response relationships, exploring the effects of low-dose radiation exposure, and studying the variability in individual responses to radiation exposure.
The goal of this research topic is to delve into every aspect of radiobiology to enhance our understanding of the cellular and molecular mechanisms leading to tumor and normal tissue responses to ionizing radiation. The focus includes elucidating radiation-induced resistance, strategies for sensitizing radiation therapy, identifying biomarkers indicative of radiation response, investigating the synergy between radiation and immunotherapy, exploring targeted radiation therapy, data integration and analysis, evaluating low-dose effects, and advancing dosimetry approaches.
In terms of scope, this research topic is primarily concerned with the biological impact of radiation, with a particular emphasis on tumor metabolism, biomarkers, and genetic factors influencing an individual's response to radiation, the tumor microenvironment, and innovative anti-cancer therapeutic approaches.
We welcome original research articles and comprehensive reviews covering these diverse topics. However, manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
The goal of this research topic is to delve into every aspect of radiobiology to enhance our understanding of the cellular and molecular mechanisms leading to tumor and normal tissue responses to ionizing radiation. The focus includes elucidating radiation-induced resistance, strategies for sensitizing radiation therapy, identifying biomarkers indicative of radiation response, investigating the synergy between radiation and immunotherapy, exploring targeted radiation therapy, data integration and analysis, evaluating low-dose effects, and advancing dosimetry approaches.
In terms of scope, this research topic is primarily concerned with the biological impact of radiation, with a particular emphasis on tumor metabolism, biomarkers, and genetic factors influencing an individual's response to radiation, the tumor microenvironment, and innovative anti-cancer therapeutic approaches.
We welcome original research articles and comprehensive reviews covering these diverse topics. However, manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Radiobiology, dosimetry, radio-immunotherapy, molecular radionuclide therapy, tumor microenvironment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
