About this Research Topic
This Research Topic invites original research articles, reviews, and perspectives covering a wide range of topics related to the mechanisms of glioma immune tolerance in the context of the microenvironment. Potential areas of interest include, but are not limited to:
1. Immune Checkpoint Pathways: Investigating the role of immune checkpoint molecules, such as PD-1, CTLA-4, and others, in glioma immune tolerance
2. Tumor-Infiltrating Immunosuppressive Cells: Understanding the interactions and functions of regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and other immunosuppressive cell populations within the glioma microenvironment
3. Cytokine and Chemokine Profiling: exploring the secretion and impact of various cytokines and chemokines that mediate immunosuppression in gliomas
4. Genetic and Epigenetic Influences: Investigating genetic mutations and epigenetic alterations in glioma cells that contribute to immune escape mechanisms
5. Therapeutic Interventions: Presenting preclinical and clinical studies on immunotherapeutic approaches targeting glioma immune tolerance, including immune checkpoint inhibitors, adoptive T-cell therapies, and novel treatment modalities
Keywords: glioma
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.