About this Research Topic
In the fast-evolving landscape of cancer immunotherapies, where the focus predominantly rests upon enhancing antitumor responses, there is an often-neglected dimension – the host. The intricate interplay between the tumor and the host's energetic status (or, in other words, the patient’s overall health condition) has been an overlooked angle in the pursuit of advancing immunotherapies. Substantial epidemiological evidence has shown the significant role that a patient's overall condition (including elements such as body composition, diet, sleep patterns, stress levels, exercise interventions, and levels of fatigue, among others) plays in cancer incidence, treatment response, and, ultimately, overall survival; however, it is not often incorporated into precision medicine strategies in immuno-oncology.
This Research Topic aims to spotlight the patient's energetic status, exploring integrative health factors from a patient (host) perspective, highlighting their influence on various immunotherapeutic modalities, including cell therapy, immune checkpoint therapy, and cancer vaccines. By fostering a multidisciplinary approach, this Research Topic seeks to bridge the gaps between immuno-oncology, internal medicine, exercise physiology, and nutrition, offering a comprehensive view of the intricate relationship between the host's energetic status and the success of cancer immunotherapy.
We are interested in Original Research and Review/Mini Review articles focusing on, but not limited to, the following areas and their effect on antitumor immunity and immunotherapy response:
Body composition: diet-induced and genetic models of obesity, malnutrition, aging and body wasting/cachexia; body composition measured by bioelectrical impedance, dual-energy X-ray absorptiometry, body density, and total body water estimates
Autonomic nervous system, stress-related hormones, and mental stress: sympathetic/parasympathetic system (muscle sympathetic nerve activity, heart rate variability, adrenergic/cholinergic balance); stress hormones (adrenal and adrenocortical hormone axis, renin-angiotensin system); psychological markers and signs of chronic stress; sleep, sleep patterns, and chronobiology studies
Cancer-related fatigue: preclinical models of effort intolerance; fatigue assessment scales/clinical diagnosis; cancer-related fatigue as immune related adverse event (iRAE); biomarkers of cancer-related fatigue
Exercise levels: preclinical models of exercise (voluntary and intensity-controlled, timing/duration/intensity effect on immune responses to exercise); physical activity inferred by validated questionnaires, measurable targets, and biopotentials (METs, heart rate response, body temperature, accelerometer); clinical and population-based exercise interventions
Nutrition: macro and micronutrient composition and modulation; impact of specific dietary approaches (Mediterranean, fasting, intermittent fasting), dietary supplements (vitamins, specific amino acids and lipids); gut microbiota and role of dietary habits and interventions on gut microbiota composition
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Dr. Zohreh Amoozgar is an employee at Sanofi, which is involved in drug and vaccine development. The other topic editors declare no competing interests with regard to the topic theme.
This Research Topic aims to spotlight the patient's energetic status, exploring integrative health factors from a patient (host) perspective, highlighting their influence on various immunotherapeutic modalities, including cell therapy, immune checkpoint therapy, and cancer vaccines. By fostering a multidisciplinary approach, this Research Topic seeks to bridge the gaps between immuno-oncology, internal medicine, exercise physiology, and nutrition, offering a comprehensive view of the intricate relationship between the host's energetic status and the success of cancer immunotherapy.
We are interested in Original Research and Review/Mini Review articles focusing on, but not limited to, the following areas and their effect on antitumor immunity and immunotherapy response:
Body composition: diet-induced and genetic models of obesity, malnutrition, aging and body wasting/cachexia; body composition measured by bioelectrical impedance, dual-energy X-ray absorptiometry, body density, and total body water estimates
Autonomic nervous system, stress-related hormones, and mental stress: sympathetic/parasympathetic system (muscle sympathetic nerve activity, heart rate variability, adrenergic/cholinergic balance); stress hormones (adrenal and adrenocortical hormone axis, renin-angiotensin system); psychological markers and signs of chronic stress; sleep, sleep patterns, and chronobiology studies
Cancer-related fatigue: preclinical models of effort intolerance; fatigue assessment scales/clinical diagnosis; cancer-related fatigue as immune related adverse event (iRAE); biomarkers of cancer-related fatigue
Exercise levels: preclinical models of exercise (voluntary and intensity-controlled, timing/duration/intensity effect on immune responses to exercise); physical activity inferred by validated questionnaires, measurable targets, and biopotentials (METs, heart rate response, body temperature, accelerometer); clinical and population-based exercise interventions
Nutrition: macro and micronutrient composition and modulation; impact of specific dietary approaches (Mediterranean, fasting, intermittent fasting), dietary supplements (vitamins, specific amino acids and lipids); gut microbiota and role of dietary habits and interventions on gut microbiota composition
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Dr. Zohreh Amoozgar is an employee at Sanofi, which is involved in drug and vaccine development. The other topic editors declare no competing interests with regard to the topic theme.
Keywords: immunotherapy, cell therapy, cancer vaccines, immune checkpoint therapy, body composition, exercise, nutrition, stress, autonomic nervous system, lifestyle factors, tumor-host interactions
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
