Evaluating Nanotechnology Efficacy and Biocompatibility in Oral Health Applications

The field of nanomedicine is rapidly advancing, offering significant potential to revolutionize oral health care. By operating at the nanoscale, researchers have developed innovative technologies with unique properties that are transforming the diagnosis, prevention, and treatment of various oral diseases. Despite these advancements, several challenges persist in applying nanotechnologies to oral medicine. These include the dynamic nature of saliva flow, the highly diverse oral microbiome and microenvironments, and the anatomical complexity of the oral cavity, which encompasses both mucosal and dental hard tissues. Additionally, the production, use, and disposal of nanomaterials may not be cost-effective and could pose environmental risks. Recent studies have shown promising results in the development of nanoparticles, nanosensors, nanorobotics, and nanofluidic devices, which offer precision-guided, safe, and affordable therapeutic modalities. However, there remains a need for further investigation into their in vivo and clinical efficacy, biocompatibility, and cost-effectiveness to fully realize their potential in oral health care.

This Research Topic aims to explore the advancements in nanomedicine for transforming oral health by focusing on the development and application of nanotechnologies for diagnosis, prevention, and treatment. The main objectives include evaluating the in vivo and clinical efficacy of emerging nanotechnologies, assessing their biocompatibility, and determining their cost-effectiveness. Specific questions to be addressed include how these technologies can be optimized for use in the complex oral environment and what modifications are necessary to enhance traditional dental materials using nanotechnologies.

To gather further insights in the application of nanotechnologies in oral health, we welcome articles addressing, but not limited to, the following themes:

- Development of new nanomaterials and nanotechnologies with potential applications in oral health.
- In vitro, in vivo, and clinical evaluations of nanotechnology-based approaches.
- Modification and enhancement of traditional dental materials using nanotechnologies.
- Review articles on existing and emerging nanomaterials and nanotechnologies in oral health.