About this Research Topic
Skin appendages, including hair follicles, sweat glands and sebaceous glands, are critical for skin functions such as aesthetics, heat dissipation, perception of the outside world and antibacterial defense. However, after a large area of skin injury, although the dermis and epidermis may be repaired, skin appendages cannot be regenerated. This negatively affects the quality of life of the patient, which cannot be ignored in the field of regenerative medicine. In addition, accessory stem cells from both hair follicles and sweat glands can participate in epidermal repair, and may inhibit the formation of scars by secreting cytokines etc.
Sweat gland and hair follicle cells are difficult to extract and expand in vitro, and their extraction could cause secondary damage to patients. Therefore, the construction of exogenous accessory cells is important to promote the regeneration of these skin appendages. The tissue microenvironment plays an important role in cell proliferation and differentiation, and artificially changing this developmental microenvironment under physiological conditions may induce them to differentiate along sweat glands or hair follicle differentiation pathways. The complexity of skin appendage-permissive tissue microenvironment, including relevant biochemical factors, physical scaffolders and vascular and nerve factors, makes it difficult to reconstruct this in vitro. However, this may be possible with biological 3D printing technology, which integrates computer-aided design, computer-aided manufacturing, computer numerical control, precision servo drive, biological materials, cell biology and molecular biology and other disciplines and technologies. It can reconstruct the physiological structure of tissues in vitro and lay a foundation for the reconstruction of the microenvironment to induce cell and tissue regeneration.
The purpose of this research topic is to establish more methods to promote skin appendage regeneration to facilitate more optimal skin function including via the inhibition of scar formation. Clarifying the role of immune cells, accessory cells and scar fibroblasts can lay a theoretical foundation for clinical treatment of skin appendage regeneration.
Original research articles and critical review articles are welcomed.
• 3D bioprinting, functional neural network reestablishment and skin appendage regeneration;
• skin appendage cell isolation and culture, hair follicle regeneration;
• sweat gland cell induction and sweat gland regeneration;
• immune cell involvement in skin appendage cell repair and regeneration.
Sweat gland and hair follicle cells are difficult to extract and expand in vitro, and their extraction could cause secondary damage to patients. Therefore, the construction of exogenous accessory cells is important to promote the regeneration of these skin appendages. The tissue microenvironment plays an important role in cell proliferation and differentiation, and artificially changing this developmental microenvironment under physiological conditions may induce them to differentiate along sweat glands or hair follicle differentiation pathways. The complexity of skin appendage-permissive tissue microenvironment, including relevant biochemical factors, physical scaffolders and vascular and nerve factors, makes it difficult to reconstruct this in vitro. However, this may be possible with biological 3D printing technology, which integrates computer-aided design, computer-aided manufacturing, computer numerical control, precision servo drive, biological materials, cell biology and molecular biology and other disciplines and technologies. It can reconstruct the physiological structure of tissues in vitro and lay a foundation for the reconstruction of the microenvironment to induce cell and tissue regeneration.
The purpose of this research topic is to establish more methods to promote skin appendage regeneration to facilitate more optimal skin function including via the inhibition of scar formation. Clarifying the role of immune cells, accessory cells and scar fibroblasts can lay a theoretical foundation for clinical treatment of skin appendage regeneration.
Original research articles and critical review articles are welcomed.
• 3D bioprinting, functional neural network reestablishment and skin appendage regeneration;
• skin appendage cell isolation and culture, hair follicle regeneration;
• sweat gland cell induction and sweat gland regeneration;
• immune cell involvement in skin appendage cell repair and regeneration.
Keywords: sweat gland, skin appendage, regeneration, 3D bioprinting
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