About this Research Topic
Allergy and autoimmunity are two distinct conditions characterized by dysregulated immune responses to normally tolerated antigens. Allergy manifests as an IgE-mediated response with a predominant Th2 profile, involving cytokines such as IL-4, IL-5, and IL-13. In contrast, autoimmune diseases like rheumatoid arthritis are associated with Th1/Th17 responses and the presence of IgG autoantibodies. Despite their apparent differences, it is increasingly recognized that these diseases may share underlying mechanisms. These include genetic predisposition, microbiota, impaired epithelial barriers, interactions between T and B cells, effector cell involvement, and triggers leading to chronic inflammation. Understanding these shared pathways is essential for unravelling the complex interplay between allergy and autoimmunity and could offer new therapeutic insights.
This Research Topic aims to bridge the two distinct domains of allergy and autoimmunity by exploring the potential shared mechanisms underlying these immune dysregulation conditions. Additionally, we seek to explore the diagnostic and therapeutic tools that can be learned and applied between these two domains.
Suitable themes for manuscripts include, but are not limited to:
1) Epidemiological studies of autoimmune and allergic diseases associations.
2) Genetic factors and their contribution to the development of allergic and autoimmune diseases.
3) Mechanisms underlying the breakdown of immune tolerance and epithelial barriers in autoimmune and allergic diseases.
4) Immune cell interactions and crosstalk in the context of allergy and autoimmunity.
5) The role of epithelial barriers in allergic and autoimmune disease.
6) Immunomodulatory therapies for allergy and autoimmune diseases.
7) The role of microbiota in modulating immune dysregulation in allergy and autoimmune diseases.
8) Autoantigens and allergens: commonalities and differences in their recognition and immune response
9) Immunometabolism and its impact on immune dysregulation in allergy and autoimmune diseases.
All article types accepted by Frontiers are welcome.
This Research Topic aims to bridge the two distinct domains of allergy and autoimmunity by exploring the potential shared mechanisms underlying these immune dysregulation conditions. Additionally, we seek to explore the diagnostic and therapeutic tools that can be learned and applied between these two domains.
Suitable themes for manuscripts include, but are not limited to:
1) Epidemiological studies of autoimmune and allergic diseases associations.
2) Genetic factors and their contribution to the development of allergic and autoimmune diseases.
3) Mechanisms underlying the breakdown of immune tolerance and epithelial barriers in autoimmune and allergic diseases.
4) Immune cell interactions and crosstalk in the context of allergy and autoimmunity.
5) The role of epithelial barriers in allergic and autoimmune disease.
6) Immunomodulatory therapies for allergy and autoimmune diseases.
7) The role of microbiota in modulating immune dysregulation in allergy and autoimmune diseases.
8) Autoantigens and allergens: commonalities and differences in their recognition and immune response
9) Immunometabolism and its impact on immune dysregulation in allergy and autoimmune diseases.
All article types accepted by Frontiers are welcome.
Keywords: Allergy, autoimmunity, inflammation, B cells, Th2, Th17, Treg, IgE, IgG, epithelial barrier, microbiota, autoantigens, allergens
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
