Community Series in C-Reactive Protein in Age-Related Disorders - Volume III

  • 2,388

    Total downloads

  • 8,508

    Total views and downloads

Submit your idea

You will be redirected to our submission process.

Submit your manuscript summarySubmit your manuscript

About this Research Topic

Submission closed

Background

Chronic inflammation and immune-mediated processes are pivotal to the pathogenic progression of multiple age-related diseases, such as cardiovascular disease (CVD), cancer, age-related macular degeneration (AMD), Alzheimer’s disease and, and type II diabetes. This chronic low-grade inflammatory status associated with ageing, named “inflammaging” plays a role in the emergence and progression of such age-related disorders. Indeed, increased levels of systemic acute-phase reactants represent a risk factor for age-related diseases.

C-reactive protein (CRP) is the prototypical acute-phase reactant and an active regulator of the innate immune system. It is considered to be a serum biomarker for chronic inflammation, CVD, diabetes, Alzheimer, and also AMD. Increased CRP levels are also associated with more severe forms of the new COVID19, where age is considered the main risk factor for poor outcome. CRP localizes to damaged tissue where it leads to complement activation and further tissue damage. Indeed, it has been identified in vascular, cerebral and ocular lesions, but little is known about its function in the context of disease onset and progression in inflammaging. Besides activating the classical complement pathway, CRP up-regulates the expression of adhesion molecules, and increases cytokine release from endothelial cells, neutrophils and macrophages. In plasma, CRP typically exists as a cyclic pentamer (pCRP) composed of five non-covalently linked subunits. However, pCRP can undergo dissociation into its monomeric subunits, thereby acquiring distinct biological functionality. Oxidative stress and bioactive lipids from activated or damaged cells present during inflammatory responses can dissociate pCRP. This alternative conformation of CRP termed monomeric CRP (mCRP) represents the tissue-based insoluble form of CRP and unlike pCRP, it displays a proinflammatory and prothrombotic phenotype in several cell types. Indeed, recent evidence suggests that mCRP may be an active player in the progression of age-related diseases such as cardiovascular disorders, Alzheimer, and AMD. A better understanding of the CRP activation and dissociation mechanism is essential to develop therapeutic strategies to minimize tissue injury. Therefore, reducing inflammation-mediated tissue injury by therapeutic inhibition might improve the outcome of age-related disorders. One of the major focuses of this second series is therapeutic translation and the possible role of C-reactive protein monitoring and manipulation in disease pathogenesis and particularly in age-related disorders.

Despite the recognition of the importance of chronic inflammation in age-related pathologies, the role of acute-phase reactants and the mechanisms underlying the inflammatory regulation in these disorders are not fully understood.

This Research Topic will cover a wide range of subjects in CRP and acute-phase reactants in chronic inflammation and age-related diseases. Original Research, Review, Mini Review, Perspective, Commentary, and Opinion articles are welcome to this Research Topic. Potential topics include, but are not limited to:

1. Mechanisms regulating inflammation in age-related diseases.
2. The role of CRP and acute phase reactants in age-related diseases.
3. CRP-mediated inflammation and signaling pathways.
4. Inflammatory markers and CRP in the diagnosis of age-related disorders.
5. Chronic inflammation in age-related diseases (Alzheimer, cardiovascular diseases, age-related macular degeneration, type II diabetes, cancer, etc).
6. CRP and inflammaging.
7. CRP in COVID-19 and other viral conditions.
8. Meta-analysis and bioinformatics on CRP.
9. Genetics and epigenetics studies on CRP.
10. CRP in cancer.

This Research Topic is the third volume of the “Community Series in C-Reactive Protein in Age-Related Disorders”. Please see the first volume here, and the second volume here.

Keywords: C-reactive protein, Inflammation, Inflammaging, Age-Related Disorders

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Impact

  • 8,508Topic views
  • 5,509Article views
  • 2,388Article downloads
View impact