About this Research Topic
Viral Chimeric Antigen Receptor T-cell (CAR-T) therapy has achieved notable success against hematological malignancies, but applying it to solid tumors faces hurdles like low tumor infiltration and CAR-T cell persistence. Imaging-driven personalized strategies hold promise for enhancing outcomes by enabling real-time tracking and visualization of CAR-T cells in tumors, aiding in understanding biodistribution, trafficking, and functionality.
This research proposal aims to decipher the role imaging techniques having the greatest potential to enhance CAR-T therapy by enhancing the assessment of CAR-T cell biodistribution, trafficking kinetics, targeting, and monitoring within solid tumors.
This research proposal invites contributions from researchers and experts in the fields of cancer immunotherapy, molecular imaging, and nanomedicine. We encourage submissions that encompass, but are not limited to, the following areas:
● Development of imaging-compatible viral CAR-T vaccines: Studies focusing on the design and engineering of viral vectors that enable co-expression of imaging reporter genes, allowing for non-invasive visualization and tracking of CAR-T cells in vivo.
● Investigating Imaging-Enhanced CAR-T Biodistribution and Trafficking: Explore the role of imaging techniques in improving the assessment of CAR-T cell biodistribution, trafficking kinetics, and targeting within solid tumors, leading to more effective cancer immunotherapy strategies.
● Innovative Imaging Probe Development: Focus on the development of novel imaging probes, nanoparticles, molecular probes, or contrast agents, tailored to enhance the visualization and targeting of viral CAR-T cells in the tumor microenvironment.
● Translational and Clinical Implications of Imaging-Guided CAR-T Therapy: Explore the feasibility, safety, and clinical translation of imaging-guided viral CAR-T vaccines, encompassing studies involving preclinical models and early-phase clinical trials to advance the practical application of this approach.
This research proposal aims to decipher the role imaging techniques having the greatest potential to enhance CAR-T therapy by enhancing the assessment of CAR-T cell biodistribution, trafficking kinetics, targeting, and monitoring within solid tumors.
This research proposal invites contributions from researchers and experts in the fields of cancer immunotherapy, molecular imaging, and nanomedicine. We encourage submissions that encompass, but are not limited to, the following areas:
● Development of imaging-compatible viral CAR-T vaccines: Studies focusing on the design and engineering of viral vectors that enable co-expression of imaging reporter genes, allowing for non-invasive visualization and tracking of CAR-T cells in vivo.
● Investigating Imaging-Enhanced CAR-T Biodistribution and Trafficking: Explore the role of imaging techniques in improving the assessment of CAR-T cell biodistribution, trafficking kinetics, and targeting within solid tumors, leading to more effective cancer immunotherapy strategies.
● Innovative Imaging Probe Development: Focus on the development of novel imaging probes, nanoparticles, molecular probes, or contrast agents, tailored to enhance the visualization and targeting of viral CAR-T cells in the tumor microenvironment.
● Translational and Clinical Implications of Imaging-Guided CAR-T Therapy: Explore the feasibility, safety, and clinical translation of imaging-guided viral CAR-T vaccines, encompassing studies involving preclinical models and early-phase clinical trials to advance the practical application of this approach.
Keywords: multimodal imaging, MRI, PET, CAR-T, optical imaging, cell tracking
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
