About this Research Topic
The central nervous system is a complex organ, intercellular crosstalk and immunoregulation play an indispensable role in physiological function and pathogenesis. Chronic neuroinflammation from the subventricular zone initiates neuroimmunology which is conducive to brain development. Furthermore, immunoregulation participates in many kinds of cerebral diseases, such as neurodegeneration, stroke, brain injury, and tumors. Defined as a double-edged sword, these immune-related factors give rise to protecting, repairing, and damaging the brain in different microenvironments. As a result, we need to further explore the interactions between neurons, glia, and immunocyte to understand neuroimmunology and neuroinflammation on cerebral stability and mechanisms of various cerebral pathophysiology mechanisms.
In this topic, we will focus on intercellular crosstalk, neuroinflammation, and immunosuppression related to brain development and illness in the central nervous system, such as blood-brain-barrier, microglia/macrophage polarization, neutrophil trap net, reactive oxygen species, glial cytokines, immunocyte recruitment and so on. Additionally, organoids and 3D printing for intercellular crosstalk are welcome. Furthermore, it is interesting in novel pharmacological mechanisms for the regulation of neuroimmunology. These subjects will contribute to understanding the intercellular regulation, immune homeostasis, and immune imbalance in cerebral pathophysiological processes, and emerging novel strategies for immunoregulation and immunotherapy.
We invite submissions of Original Research Articles, Reviews, and Perspectives on the Topic. The submissions may cover a wide range of areas, including but not limited to:
-The crosstalk between nerve cells and immune cells for immunoregulation in brain injury, cerebral hemorrhage and brain tumor.
- Organoids and 3D-printing to imitate brain for immunoregulation and immunotherapy.
-Neuroimmune-related computational models, machine learning and data mining to predict progression and prognosis of brain injury, cerebral hemorrhage and brain tumor.
-Immunologic factors for disease progression.
In this topic, we will focus on intercellular crosstalk, neuroinflammation, and immunosuppression related to brain development and illness in the central nervous system, such as blood-brain-barrier, microglia/macrophage polarization, neutrophil trap net, reactive oxygen species, glial cytokines, immunocyte recruitment and so on. Additionally, organoids and 3D printing for intercellular crosstalk are welcome. Furthermore, it is interesting in novel pharmacological mechanisms for the regulation of neuroimmunology. These subjects will contribute to understanding the intercellular regulation, immune homeostasis, and immune imbalance in cerebral pathophysiological processes, and emerging novel strategies for immunoregulation and immunotherapy.
We invite submissions of Original Research Articles, Reviews, and Perspectives on the Topic. The submissions may cover a wide range of areas, including but not limited to:
-The crosstalk between nerve cells and immune cells for immunoregulation in brain injury, cerebral hemorrhage and brain tumor.
- Organoids and 3D-printing to imitate brain for immunoregulation and immunotherapy.
-Neuroimmune-related computational models, machine learning and data mining to predict progression and prognosis of brain injury, cerebral hemorrhage and brain tumor.
-Immunologic factors for disease progression.
Keywords: Neuroinflammation, Immunosuppression, Neuroimmunology, Brain function, Cerebral disease, Interaction
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
