About this Research Topic
Dental tissue is composed of a unique combination of multiple elements derived from epithelial cells and neural crest-derived mesenchymal stem cells. Having healthy dental tissues leads to a healthier systemic condition and an extension of healthy life expectancy. In mammals, teeth erupt once or twice, playing a vital role in grinding and serving other essential functions in our lives. However, when we lose the permanent teeth, dental stem cells become depleted and can no longer serve as a source for tooth production. Additionally, the disconnection of blood vessels leads to a decline in oxygen supply. Therefore, it becomes crucial to prevent tooth loss and maintain the integrity of the dental perivascular niche. Moreover, to preserve the natural teeth, neurovascular bundle-tissue engineering should be considered.
The current focus of the dental treatment system is primarily on delaying disease progression or removing infected tissues, which includes natural tissues. Nevertheless, our ultimate goal is to create fully functional vascularized dental tissues and explore innovative dental treatment approaches by bringing them to natural teeth closer. The prevention of dental diseases before their occurrence holds significant importance. However, there are still opportunities to establish a vascularized dental niche despite the presence of tooth decay or periodontal diseases. To maximize tooth preservation, it becomes crucial to update our understanding of the dental perivascular microenvironment from various perspectives, including macro levels, micro levels, single cell resolutions, and genomic levels.
In this Research Topic, we aim to gather innovative studies that help explore effective treatment approaches for the creation of natural dental organs and restoration of tooth functions. We welcome the submission of Original Research articles and Reviews that cover a diverse range of subtopics, including but not limited to:
• Understanding the intricate dynamics and functions of the dental perivascular niche;
• Deciphering cell-cell interaction and communication within dental tissues;
• Exploring the underlying intracellular and extracellular mechanisms involved;
• Investigating the role of stem cells in dental tissue regeneration and unraveling the signaling pathways;
• Studying the factors involved in the regulation of the dental perivascular microenvironment.
The current focus of the dental treatment system is primarily on delaying disease progression or removing infected tissues, which includes natural tissues. Nevertheless, our ultimate goal is to create fully functional vascularized dental tissues and explore innovative dental treatment approaches by bringing them to natural teeth closer. The prevention of dental diseases before their occurrence holds significant importance. However, there are still opportunities to establish a vascularized dental niche despite the presence of tooth decay or periodontal diseases. To maximize tooth preservation, it becomes crucial to update our understanding of the dental perivascular microenvironment from various perspectives, including macro levels, micro levels, single cell resolutions, and genomic levels.
In this Research Topic, we aim to gather innovative studies that help explore effective treatment approaches for the creation of natural dental organs and restoration of tooth functions. We welcome the submission of Original Research articles and Reviews that cover a diverse range of subtopics, including but not limited to:
• Understanding the intricate dynamics and functions of the dental perivascular niche;
• Deciphering cell-cell interaction and communication within dental tissues;
• Exploring the underlying intracellular and extracellular mechanisms involved;
• Investigating the role of stem cells in dental tissue regeneration and unraveling the signaling pathways;
• Studying the factors involved in the regulation of the dental perivascular microenvironment.
Keywords: stem cells, niche regulation, development, regenerative therapy, tissue engineering, skeletal stem cells, mesenchymal stem cells
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
