About this Research Topic
Disease microbiology is a vast field of research, especially encompassing the recent and rapid advancements of omics science technologies and the application of artificial intelligence. Multi-omics research in understanding the molecular basis of disease microbiology is a rapidly evolving field that explores the multitude of intricate interactions between microbes and their hosts in the context of various diseases. The human microbiome, the constellation of microorganisms residing inside and externally on our bodies, plays a crucial role in maintaining health and contributing to disease states. Traditional microbiological and molecular techniques have provided valuable insights, but they often offer a limited view of the existing complex microbial communities and their functional activities. In contrast, multi-omics approaches, such as genomics/metagenomics (microbiomics), transcriptomics/metatranscriptomics, proteomics/metaproteomics, metabolomics, and epigenomics, enable comprehensive profiling of microbial communities and analysis of their functional role and dynamics within a host. Despite these advancements, there remain significant gaps in our understanding of the precise mechanisms by which microbial communities influence disease processes, necessitating further investigation.
This research topic aims to delve deep into the role of multi-omics research in advancing a more specific understanding of the molecular basis of disease microbiology. One of the most important aspects will be to generate precise and useful (pre-clinical/clinical) information with appropriate study design. We aim to address the key challenges in this field and explore the recent advances that have the potential to revolutionize disease diagnosis, treatment, and prevention. Leveraging multi-omics technologies might help us to uncover intricate host-microbe interactions, identify disease-specific biomarkers, elucidate microbial functions, and develop targeted therapeutic interventions.
To gather further insights into the boundaries of multi-omics research in disease microbiology, we welcome articles addressing, but not limited to, the following themes:
- Role of microbiome in different diseases via multi-omics analyses.
- Host-microbe and host-microbe-environment interactions and their influence on disease pathogenesis/pathophysiology and applicability in advanced/precise diagnosis for more appropriate therapeutics.
- Identification of disease-specific biomarkers through multi-omics profiling.
- Functional profiling of microbial communities and their contribution to disease development.
- Targeted therapeutic interventions for various diseases, based on data from multi-omics studies.
- Molecular diagnostics.
- Bridging the gap between conventional and multi-omics technologies in clinical applications.
We encourage the submission of original research articles, reviews, methods, opinions, and perspectives. Manuscripts should be original and provide novel insights, present recent and cutting-edge research, or offer comprehensive reviews of the literature. We invite authors to contribute to this Research Topic, enriching the scientific community with the exploration and use of multi-omics approaches in a thorough understanding of disease microbiology and its impact on human health.
This research topic aims to delve deep into the role of multi-omics research in advancing a more specific understanding of the molecular basis of disease microbiology. One of the most important aspects will be to generate precise and useful (pre-clinical/clinical) information with appropriate study design. We aim to address the key challenges in this field and explore the recent advances that have the potential to revolutionize disease diagnosis, treatment, and prevention. Leveraging multi-omics technologies might help us to uncover intricate host-microbe interactions, identify disease-specific biomarkers, elucidate microbial functions, and develop targeted therapeutic interventions.
To gather further insights into the boundaries of multi-omics research in disease microbiology, we welcome articles addressing, but not limited to, the following themes:
- Role of microbiome in different diseases via multi-omics analyses.
- Host-microbe and host-microbe-environment interactions and their influence on disease pathogenesis/pathophysiology and applicability in advanced/precise diagnosis for more appropriate therapeutics.
- Identification of disease-specific biomarkers through multi-omics profiling.
- Functional profiling of microbial communities and their contribution to disease development.
- Targeted therapeutic interventions for various diseases, based on data from multi-omics studies.
- Molecular diagnostics.
- Bridging the gap between conventional and multi-omics technologies in clinical applications.
We encourage the submission of original research articles, reviews, methods, opinions, and perspectives. Manuscripts should be original and provide novel insights, present recent and cutting-edge research, or offer comprehensive reviews of the literature. We invite authors to contribute to this Research Topic, enriching the scientific community with the exploration and use of multi-omics approaches in a thorough understanding of disease microbiology and its impact on human health.
Keywords: Multi-Omics, Microbiome, Biomarkers, Host-Microbe Interactions, Therapeutic Interventions
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
