About this Research Topic
Postmenopausal women experience an increased risk of cardiometabolic diseases compared to women in their reproductive period. This heightened risk can be attributed to hormonal disturbances, including a decrease in estrogen and an excess of androgen, which affect various metabolic pathways and result in neurocognitive changes. The redistribution of adipose tissue towards visceral compartments is one of the key characteristics of the menopause. Consequently, postmenopausal women have an increased risk of developing insulin resistance, metabolic syndrome, type 2 diabetes, non-alcoholic fatty liver disease, hypertension and cardiovascular disease in comparison to premenopausal women. Additionally, postmenopausal women face an increased risk of experiencing neurocognitive disorders and osteoporosis with associated fractures, significantly impacting their overall quality of life during the menopausal phase.
Cardiometabolic disorders that occur during postmenopause are characterized by shared underlying pathophysiological mechanisms, specifically oxidative stress and inflammation. Despite extensive research in this area, there remains a knowledge gap in our understanding of the complex pathophysiological mechanisms that underlie estrogen deficiency, androgen excess and cardiometabolic disorders in menopause. To gain deeper insight into the complexity of these mechanisms, further studies are required to investigate novel diagnostic and prognostic biomarkers for these disturbances. This will contribute to a more comprehensive understanding of these conditions and ultimately improve patient care.
The aim of this Research Topic is to further examine the current trends, advancements, and role of oxidative stress and inflammation in metabolic disorders in postmenopausal women. Original research and review articles specifically focusing on women in postmenopausal period are welcome.
Investigations into potential topics include but are not limited to the following:
- Early diagnosis of menopause
- Exploring potential novel mechanisms linking oxidative stress, inflammation and cardiometabolic disorders in menopause
- Identification of innovative biomarkers associated to cardiometabolic disorders in menopause
- Hormone replacement therapy as a treatment option in menopause
- Exploration of therapeutic possibilities involving antioxidants and different weight-loss programs for cardio-metabolic disorders in menopause
Cardiometabolic disorders that occur during postmenopause are characterized by shared underlying pathophysiological mechanisms, specifically oxidative stress and inflammation. Despite extensive research in this area, there remains a knowledge gap in our understanding of the complex pathophysiological mechanisms that underlie estrogen deficiency, androgen excess and cardiometabolic disorders in menopause. To gain deeper insight into the complexity of these mechanisms, further studies are required to investigate novel diagnostic and prognostic biomarkers for these disturbances. This will contribute to a more comprehensive understanding of these conditions and ultimately improve patient care.
The aim of this Research Topic is to further examine the current trends, advancements, and role of oxidative stress and inflammation in metabolic disorders in postmenopausal women. Original research and review articles specifically focusing on women in postmenopausal period are welcome.
Investigations into potential topics include but are not limited to the following:
- Early diagnosis of menopause
- Exploring potential novel mechanisms linking oxidative stress, inflammation and cardiometabolic disorders in menopause
- Identification of innovative biomarkers associated to cardiometabolic disorders in menopause
- Hormone replacement therapy as a treatment option in menopause
- Exploration of therapeutic possibilities involving antioxidants and different weight-loss programs for cardio-metabolic disorders in menopause
Keywords: Cardiometabolic diseases, menopause, postmenopausal women, hormone-replacement therapy, oxidative stress, inflammation
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