About this Research Topic
Tremor disorders such as Parkinson’s disease (PD) are common complex disorders caused by complex interactions of genetic and environmental factors. Identifying gene-environment interactions is vital to understand disease mechanisms and to develop therapeutics. There is some evidence for a role of a number of environmental exposures (e.g. pesticides, diet) in modulating Parkinson’s disease (PD) risk. The role of the exposome in PD is an emerging area of investigation and is largely understudied. Understanding environmental influences, including the external environment, lifestyle, behavior, and diet, identifying gene-environment interactions and the resulting biological and endogenous processes are needed to move the field forward. Advancements in a number of key areas including 1) innovative smart device-based technologies for measuring the exposome (e.g. lifestyle, diet, chemical pollutants) and epidemiological assessment of exposures, 2) whole genome sequencing and variant interpretation in coding, noncoding and regulatory regions and epigenetic mechanisms, 3) Multi-omic and single cell-based technologies should help elucidate how environmental exposures impact PD.
The aim of this comprehensive review is to consolidate the existing evidence and provide an up-to-date overview of recent research on gene-environment (GxE) interactions and the exposome in PD. This review will synthesize findings from various studies, highlighting the molecular mechanisms underlying environmental exposures in PD, the role of the exposome in these conditions, the impact of gene-environment interactions on neural circuits, the effects of environmental pollutants and epigenetic mechanisms, and the advancements in smart device-based technologies and multi-omic approaches for assessing the exposome in movement and tremor disorders. By critically analyzing the current state of knowledge and identifying research gaps, this review will also provide insights into future opportunities for advancing the field.
This special research topic seeks contributions that address the role of the exposome and gene-environment interactions in tremor disorders. Authors are encouraged to focus on specific themes, including:
1. Molecular Mechanisms of Environmental Exposures in PD
2. The role of the exposome in PD
2. Gene-Environment Interactions and disruption of neural circuits in PD
3. Effects of environmental pollutants and epigenetic mechanisms in PD
4. Advances in smart device-based technologies for measuring the exposome in movement/tremor disorders
5. Using multiomic and single-cell-based technologies to study environmental exposures
Types of Manuscripts: 1)Review articles and 2) Original manuscripts
The aim of this comprehensive review is to consolidate the existing evidence and provide an up-to-date overview of recent research on gene-environment (GxE) interactions and the exposome in PD. This review will synthesize findings from various studies, highlighting the molecular mechanisms underlying environmental exposures in PD, the role of the exposome in these conditions, the impact of gene-environment interactions on neural circuits, the effects of environmental pollutants and epigenetic mechanisms, and the advancements in smart device-based technologies and multi-omic approaches for assessing the exposome in movement and tremor disorders. By critically analyzing the current state of knowledge and identifying research gaps, this review will also provide insights into future opportunities for advancing the field.
This special research topic seeks contributions that address the role of the exposome and gene-environment interactions in tremor disorders. Authors are encouraged to focus on specific themes, including:
1. Molecular Mechanisms of Environmental Exposures in PD
2. The role of the exposome in PD
2. Gene-Environment Interactions and disruption of neural circuits in PD
3. Effects of environmental pollutants and epigenetic mechanisms in PD
4. Advances in smart device-based technologies for measuring the exposome in movement/tremor disorders
5. Using multiomic and single-cell-based technologies to study environmental exposures
Types of Manuscripts: 1)Review articles and 2) Original manuscripts
Keywords: Tremor, Parkinson’s disease, Environmental factors, gene-environment interactions, exposome, genetics, susceptibility genes, modifiers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
