About this Research Topic
The immune responses underlying SARS-CoV2 infection are complex as are the immunopathology associated with infection and resolution in which multiple organs and tissues are affected. This is highlighted by the occurrence of prolonged pathology and symptoms termed “Long Covid” well after resolution of infection and also coupled with the high mutation rate of the virus. Preclinical models allow for mechanistic dissection of the pleiotropic effects of the virus as well as vaccine responses. These can include mouse models but also involve non-human primate models, all of which have advantages but limitations that must be considered when extrapolating to humans. Preclinical models may also include in vitro modeling components.
This collection seeks manuscripts consisting of reviews or primary data that may include, but are not limited to:
• Different aspects of preclinical CoV2 modeling in which the pathogenesis of the virus and the role the immune system plays in various affected tissues (pulmonary, hematopoietic, neurological) and readouts used.
• Factors that affect immune responses (age, sex, body fat, species, genetic alteration allowing for CoV2 infection, strain of mouse, time after challenge, etc)
• Similarities and differences with original SARS-CoV models
• Components of the virus or vaccine (formulation, adjuvants, target antigen) itself which can affect immune responses and the different components of the immune responses (innate, adaptive, cytokines) will all be covered.
Attempts to link to clinical data or other species also are encouraged. Particular attention will be given for acknowledging the caveats or limitations of the preclinical models used and issues still needing to be addressed.
Keywords: SARS-CoV2, infection, preclinical modeling, immune, vaccines, immunopathology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.