About this Research Topic
The prevalence of kidney stones, which affects the urinary system, has increased worldwide in the past decade. According to their composition, kidney stones are mainly categorized as oxalate, phosphate, or uric acid stones. The recurrence risk of kidney stones can be as high as 50% following the first kidney colic within five years. Kidney stones are now increasingly recognized as the result of a systemic disease. The purpose of this Research Topic is to provide up-to-date reviews and original articles that highlight work in the genomics of stone disease, which we hope will not only integrate our current understanding but crystallize nascent questions that will help move the field forward.
This research topic aims to inspire novel insights into the mechanisms, novel therapeutic targets, and effective precision medicine based on the genomics of the urinary system. We welcome Original Research articles, Review articles, Mini Reviews, Case Reports, Clinical Trials, and Perspectives that address the fundamental understanding of mechanisms, as well as the potential novel therapy for genetics in urinary stones.
Topics of Interest:
1. Monogenic cause of kidney stone or nephrolithiasis
2. Lipid or energy metabolic disorders related to renal genomics
3. Genomics of immunotherapy for kidney stones and kidney injury (including genes related to inflammation or oxidative stress)
4. Role of inflammatory immune cell components comprising the microenvironment in stone disease
5. Role of urinary microbiota and gut microbiota in the progression of kidney stones
Please note: All submissions must be in scope for this journal section and follow journal guidelines for article submission. In particular, Case Reports must include annotated CARE guidelines and other articles are encouraged to include an annotated EQUATOR checklist appropriate for their article type.
This research topic aims to inspire novel insights into the mechanisms, novel therapeutic targets, and effective precision medicine based on the genomics of the urinary system. We welcome Original Research articles, Review articles, Mini Reviews, Case Reports, Clinical Trials, and Perspectives that address the fundamental understanding of mechanisms, as well as the potential novel therapy for genetics in urinary stones.
Topics of Interest:
1. Monogenic cause of kidney stone or nephrolithiasis
2. Lipid or energy metabolic disorders related to renal genomics
3. Genomics of immunotherapy for kidney stones and kidney injury (including genes related to inflammation or oxidative stress)
4. Role of inflammatory immune cell components comprising the microenvironment in stone disease
5. Role of urinary microbiota and gut microbiota in the progression of kidney stones
Please note: All submissions must be in scope for this journal section and follow journal guidelines for article submission. In particular, Case Reports must include annotated CARE guidelines and other articles are encouraged to include an annotated EQUATOR checklist appropriate for their article type.
Keywords: Stone disease, Urinary system, Kidney stone, Metabolic disorder, Genetics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
