About this Research Topic
Over the last decades, a significant progress has been made in understanding the key cellular and molecular mechanisms involved on metabolic disorders. Emerging evidence have highlighted that both vascular endothelial cells (EC) and T lymphocytes play a crucial role in regulating glucose and lipid metabolism. Such cells are central effectors in the inflammatory response, tissue homeostasis, and regulation of nutrient bioavailability. Additionally, EC and T cells can influence several biological aspects related to energy intake and expenditure on neighborhood cells and tissues. Based on these findings, recent studies testing T cell-based therapies have shown promising outcomes in managing metabolic diseases such as diabetes, obesity, and non-alcoholic fatty liver disease. Altogether, such findings pinpoint the EC and T cells as promising targets for the treatment of metabolic diseases. However, despite the advance obtained over the last years, further research is still necessary to unravel the specific roles of EC and T cells, as well as understanding the underlying mechanisms involved in EC:T cell-mediated metabolic regulation. Among the areas that require further research, some points are of particular interest for this research topic:
1. Elucidating the precise effects of EC and T cells on glucose metabolism: Although it is known that soluble factors secreted by EC and T cells (e.g. cytokines, chemokines, hormones) impact glucose homeostasis, further investigation is needed to understand the intricate mechanisms by which EC:T cells-derived soluble factors regulate glucose synthesis, utilization, and storage in different metabolic tissues.
2. Understanding the effects of EC and T cells on lipid metabolism: The influence of soluble factors released by EC:T cells on lipid metabolism, including lipogenesis, lipolysis, and adipose tissue browning, is an subject that requires deeper exploration. A better understanding of the EC:T cells-mediated regulation of lipid metabolism can potentially lead to novel therapeutic strategies for metabolic disorders.
3. Uncovering new molecular targets to support drug therapeutic: The synthesis, secretion, and transport of EC:T cells-derived soluble factors are intricate processes that are still not fully understood. Investigating these aspects can provide valuable insights into the regulation of EC:T cells phenotype and their impact on metabolic homeostasis.
1. Elucidating the precise effects of EC and T cells on glucose metabolism: Although it is known that soluble factors secreted by EC and T cells (e.g. cytokines, chemokines, hormones) impact glucose homeostasis, further investigation is needed to understand the intricate mechanisms by which EC:T cells-derived soluble factors regulate glucose synthesis, utilization, and storage in different metabolic tissues.
2. Understanding the effects of EC and T cells on lipid metabolism: The influence of soluble factors released by EC:T cells on lipid metabolism, including lipogenesis, lipolysis, and adipose tissue browning, is an subject that requires deeper exploration. A better understanding of the EC:T cells-mediated regulation of lipid metabolism can potentially lead to novel therapeutic strategies for metabolic disorders.
3. Uncovering new molecular targets to support drug therapeutic: The synthesis, secretion, and transport of EC:T cells-derived soluble factors are intricate processes that are still not fully understood. Investigating these aspects can provide valuable insights into the regulation of EC:T cells phenotype and their impact on metabolic homeostasis.
Keywords: immune cell, endothelial cell, metabolic
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