About this Research Topic
The imbalance of intestinal immunity due to dysbiosis of gut microbiota is considered a significant factor contributing to inflammatory bowel disease (IBD). At the same time, dysbiosis of the gut microbiota is thought to be associated with a variety of neurological disorders. Researchers studying IBD have recognized that patients with IBD have a bidirectional brain-gut axis connection through the gut microbiota. Gut microbiota-brain connections include neural pathways, endocrine pathways, intestinal immunity, intestinal microbial metabolic systems, and the intestinal mucosal barrier and blood-brain barrier. The gut-brain axis has now changed to the microbiota-gut-brain axis. Understanding the relationship between the gut-brain axis, particularly the link between IBD and neurological disorders, is crucial, as psychiatric problems are frequently reported in IBD patients. Dysbiosis of the gut microbiota may have important implications in both systems of disease. Thus, research on the microbiota-gut-brain axis may have an unpredictable effect on the treatment and prognosis of IBD.
This Research Topic aims to further understand the mechanism, treatment and prognosis of IBD in conjunction with neurological disorders by investigating the gut microbe-gut-brain axis. Gut microbiota influences our lives from birth, and as one of the important pathogenesis of IBD, a more in-depth study will be beneficial to the future treatment of IBD patients. Additionally, addressing the challenge posed by the combination of neurological disorders in IBD patients is of utmost importance. We will further investigate the microbiota-gut-brain axis to provide more effective and individualized clinical treatment for IBD patients with co-morbid neurological disorders.
We welcome submissions focusing on, but not limited to, the following subtopics,
• Mechanism of comorbid neurological disorders in patients with IBD
• Study of pathways associated with the gut microbiota-gut-brain axis in patients with IBD
• New drug targets for IBD combined with neurological disorders caused by dysbiosis of the gut microbiota
• Exploring therapies for IBD patients with co-morbid neurological disorders, especially in relation to dysbiosis of the gut microbiota
• Significance of certain microbe for the gut microbiota-gut-brain axis in patients with IBD
• Effect of neurological disease-related therapies on the gut microbiota-gut-brain axis in IBD patients with comorbid neurological disease
• Gut microbiota-gut-brain axis and IBD pathogenesis
This Research Topic aims to further understand the mechanism, treatment and prognosis of IBD in conjunction with neurological disorders by investigating the gut microbe-gut-brain axis. Gut microbiota influences our lives from birth, and as one of the important pathogenesis of IBD, a more in-depth study will be beneficial to the future treatment of IBD patients. Additionally, addressing the challenge posed by the combination of neurological disorders in IBD patients is of utmost importance. We will further investigate the microbiota-gut-brain axis to provide more effective and individualized clinical treatment for IBD patients with co-morbid neurological disorders.
We welcome submissions focusing on, but not limited to, the following subtopics,
• Mechanism of comorbid neurological disorders in patients with IBD
• Study of pathways associated with the gut microbiota-gut-brain axis in patients with IBD
• New drug targets for IBD combined with neurological disorders caused by dysbiosis of the gut microbiota
• Exploring therapies for IBD patients with co-morbid neurological disorders, especially in relation to dysbiosis of the gut microbiota
• Significance of certain microbe for the gut microbiota-gut-brain axis in patients with IBD
• Effect of neurological disease-related therapies on the gut microbiota-gut-brain axis in IBD patients with comorbid neurological disease
• Gut microbiota-gut-brain axis and IBD pathogenesis
Keywords: inflammatory bowel disease, intestinal, brain, axis, gut microbiome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
