About this Research Topic
Angioedema without wheals (AE) is self-limiting and localized oedema presenting without urticaria, characterized by swelling of the face, lips, tongue, larynx, abdomen, genitalia or extremities. Different types of acquired and hereditary recurrent angioedema without wheals are not responsive to antihistamines and corticosteroids. Treatment requires interventions mainly targeting bradykinin pathways. Patients with AE are often misdiagnosed, translating to delays in diagnosis, which are long and common. However, if AE patients are untreated or not treated correctly, the attacks can be frequent, tremendously affecting the quality of life. Patients can be debilitated by symptoms for several weeks a year, which is also associated with a huge economical burden. Furthermore, laryngeal oedema as the most worrisome presentation of AE, if treated wrongly, can cause death by asphyxiation.
Angioedema without wheals (AE) is self-limiting and localized oedema presenting without urticaria, characterized by swelling of the face, lips, tongue, larynx, abdomen, genitalia or extremities. Different types of acquired and hereditary recurrent angioedema without wheals are not responsive to antihistamines and corticosteroids. Treatment requires interventions mainly targeting bradykinin pathways. Patients with AE are often misdiagnosed, translating to delays in diagnosis, which are long and common. However, if AE patients are untreated or not treated correctly, the attacks can be frequent, tremendously affecting the quality of life. Patients can be debilitated by symptoms for several weeks a year, which is also associated with a huge economical burden. Furthermore, laryngeal oedema as the most worrisome presentation of AE, if treated wrongly, can cause death by asphyxiation.
This Research Topic welcomes all article types accepted by Frontiers Immunology; research articles, brief research articles, reviews, and mini reviews; covering themes including, but not limited to, diagnosis, genetics, classification, biomarkers, treatment, epidemiology, quality of life, challenging case reports or case series, that provide unique insights into pathogenesis underlying angioedema without wheals and improving patient management. The submitted manuscripts must have a focus on immunology as in the description section of Frontiers in Immunology - Inflammation https://www.frontiersin.org/journals/immunology/sections/inflammation/about.
Topic Editor Prof. Anastasios E Germenis is the co-founder of the spin-off company of the University of Thessaly CeMIA SA; The other Topic Editors declare no competing interests with regard to the Research Topic subject
Angioedema without wheals (AE) is self-limiting and localized oedema presenting without urticaria, characterized by swelling of the face, lips, tongue, larynx, abdomen, genitalia or extremities. Different types of acquired and hereditary recurrent angioedema without wheals are not responsive to antihistamines and corticosteroids. Treatment requires interventions mainly targeting bradykinin pathways. Patients with AE are often misdiagnosed, translating to delays in diagnosis, which are long and common. However, if AE patients are untreated or not treated correctly, the attacks can be frequent, tremendously affecting the quality of life. Patients can be debilitated by symptoms for several weeks a year, which is also associated with a huge economical burden. Furthermore, laryngeal oedema as the most worrisome presentation of AE, if treated wrongly, can cause death by asphyxiation.
This Research Topic welcomes all article types accepted by Frontiers Immunology; research articles, brief research articles, reviews, and mini reviews; covering themes including, but not limited to, diagnosis, genetics, classification, biomarkers, treatment, epidemiology, quality of life, challenging case reports or case series, that provide unique insights into pathogenesis underlying angioedema without wheals and improving patient management. The submitted manuscripts must have a focus on immunology as in the description section of Frontiers in Immunology - Inflammation https://www.frontiersin.org/journals/immunology/sections/inflammation/about.
Topic Editor Prof. Anastasios E Germenis is the co-founder of the spin-off company of the University of Thessaly CeMIA SA; The other Topic Editors declare no competing interests with regard to the Research Topic subject
Keywords: Angioedema, angioedema without wheals, hereditary angioedema, pathogenesis, diagnosis, biomarkers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
