Pyroptosis in Endometrial Tumors

Pyroptosis is a novel inflammatory programmed cell death pathway, which relies on the protein Gasdermin D (GSDMD) to precede rapid necrotic cell death by intensive blebbing. GSDMD in human endometrial cancer cells could elicit pyroptosis and reduces the size and weight of endometrial tumors in a mouse xenograft model. However, recent findings also indicate that cells undergoing pyroptosis may not always result in cell death. The endosomal sorting complex required for transport (ESCRT) machinery family member, charged multivesicular body protein 4 (CHMP4), and other key components might remove GSDMD pores from the cell membrane, regulate inflammasome activation, and support membrane remodeling to preserve membrane integrity and reverse pyroptotic cell death. Possible prognosis and treatment strategies for endometrial cancer related to pyroptosis and GSDMD have attracted much attention over the years. Targeting CHMP4 B-related proteins may promote pyroptosis in endometrial tumors. And inducing sustained release of GSDMD and concurrent blockade of ESCRT-III proteins has also been shown to trigger tumor pyroptosis and inhibit tumor growth.

This Research Topic focuses on the relationship between pyroptosis and endometrial carcinoma. We try to investigate the mechanism of pyroptosis and elucidate the role of ESCRT proteins in reducing pyroptosis and mediating cell membrane repair in endometrial carcinoma. Our goal is to identify possible prognosis of endometrial cancer related to GSDMD or ESCRT and find more efficient and accurate biomarkers on the basis of pyroptosis, thus contributing to the early screening of patients and promoting the development of accurate treatment and immunotherapy. We hope to bring together insightful research and provide new and personalized strategies for the diagnosis, treatment, and prognosis of endometrial cancer in this Research Topic.
● Mechanisms of pyroptosis affecting endometrial carcinoma.
● Pathway of cell membrane remodeling in endometrial carcinoma.
● The relationship and interaction between pyroptosis or proteins negatively regulating pyroptosis and cell membrane remodeling in endometrial carcinoma.
● Interaction between pyroptosis and immune cells or stromal cells during the occurrence and development of endometrial carcinoma.
● Screening for new prognostic markers related to pyroptosis in endometrial carcinoma.
● Identification of potential targets related to pyroptosis in endometrial tumors immunotherapy for individualized and comprehensive treatment.

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.