About this Research Topic
This research topic aims to provide a comprehensive overview of the effects of targeting DDR with or without radiation on the activation of the innate immunity system in cancer cells, as well as its therapeutic potential. The objective is to delve into the biochemical, molecular, genomic, and proteomic studies related to radiation and/or DDR inhibitor-induced antitumor innate immunity. Furthermore, the research seeks to explore the cellular pathogen-sensing system and signaling pathways that mediate the antitumor innate immunity by radiation and/or DDR inhibitors.
To gather further insights into the role of DDR inhibitors in enhancing antitumor innate immunity, we welcome articles addressing, but not limited to, the following themes:
● Biochemical, molecular, genomic, proteomic studies related to radiation and/or DDR inhibitor-induced antitumor innate immunity
● Cellular pathogen-sensing system (not limited to DNA sensors) and signaling pathways that mediate the antitumor innate immunity by radiation and/or DDR inhibitors
● Flow cytometry, mass cytometry and/or single-cell RNA-sequencing (scRNA-seq) analyzing innate immunity of ex vivo and in vivo tumor-related models in response to radiation and DDR inhibitors
● Translational potentials of DDR inhibitors (such as inhibitors targeting PARP, ATR, ATM, DNA-PKcs, WEE1, CHK1/2) related to antitumor innate immunity.
Please note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Innate immunity, Radiation, DNA damage response, Pathogen recognition patterns, DNA sensors
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.