Current Chemical Approaches in Combating Neuroinflammation in Alzheimer's Disease (AD)

  • 1,624

    Total Downloads

  • 9,543

    Total Views and Downloads

About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 16 January 2024

Background

Alzheimer’s disease (AD) is a leading chronic neurodegenerative disorder and the primary cause of dementia, posing a significant global health threat. By 2040, it is projected that 81.1 million people worldwide will be affected by AD, with the number of dementia patients doubling every 20 years, leading to profound social, economic, and health challenges. The disease is characterized by two main hallmarks: the extracellular deposition of senile plaques composed of amyloid beta proteins and intraneuronal tangles formed with hyperphosphorylated tau units. Initially, it was believed that eliminating these plaques and tangles would halt neuroinflammation. However, later findings indicate that neuroinflammation precedes these hallmarks, contributing to severe neuronal death and synaptic dysfunction. Despite ongoing research, there are currently no approved drugs to treat neuroinflammation in AD. This inflammatory response, characterized by the production of cytokines, chemokines, and reactive oxygen species (ROS), is a complex process that requires further understanding to identify valid therapeutic targets. Although several small molecules and biomarkers are in clinical trials, many have failed, highlighting the urgent need for alternative methods and innovative therapeutic strategies.

This research topic aims to consolidate ongoing and future research on chemical approaches to combat neuroinflammation in Alzheimer's Disease. The primary objective is to explore and develop novel chemical molecules and therapeutic strategies that can effectively target neuroinflammatory processes. Key questions include identifying valid pharmacological targets, optimizing chemical compounds, and understanding the mechanistic roles of biomarkers in neuroinflammation. We also seek research that tests hypotheses related to the efficacy of receptor-based and structure-based chemical designs, as well as the potential of cutting-edge technologies like genome sequencing and CRISPR/Cas9 in regulating neuroinflammation.

To gather further insights into the chemical approaches combating neuroinflammation in Alzheimer's Disease, we welcome articles addressing, but not limited to, the following themes:
- Receptor-based or structure-based designing of chemical molecules against neuroinflammation
- Structure-Activity Relationship (SAR) based optimization of anti-inflammatory molecules
- Identification of neuroinflammatory changes involving the expression of different proteins and the development of inhibitors
- Pharmacophore analysis and identification of targets to change neuroinflammation
- Identification of novel biomarkers or mechanistic roles of biomarkers in neuroinflammatory changes
- Validation and comparison of novel biomarkers with existing biomarkers
- Cutting-edge research (e.g., genome sequencing, CRISPR/Cas9) based approaches for the regulation of neuroinflammation
- Epigenetic research studies involving neuroinflammatory changes
- Clinical/longitudinal research studies for the optimization of drugs to combat neuroinflammation in AD.


Topic Editor Dr. Dwaipayan Sen is employed by Astellas Gene Therapies. All other Topic Editors declare no competing interests with regards to the Research Topic subject

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Data Report
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion
  • Original Research

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Alzheimer's disease, chronic neurodegenerative disorder, dementia, senile plaques, tau units, neuroinflammation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and they fall under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

      In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

Impact

  • 9,543Topic views
  • 7,243Article views
  • 1,624Article downloads
View impact