Exosome-Mediated Intercellular Communications: Immune Stimulation and Suppression

Exosomes are extracellular vesicles that are released by various cell types and play critical roles in intercellular communication. Recent studies have shown that exosomes can function as mediators of immune-cell interactions and contribute to the regulation of immune responses. Specifically, exosomes, depending on surface receptor expression and molecular cargo, have been shown to stimulate or suppress the immune system. There is still much to uncover about the mechanisms through which these processes occur. Exosomes are involved in many aspects of immune function, including antigen presentation, cytokine signalling, and immune cell maturation. Additionally, they have been found to play a crucial role in immune evasion by certain malignancies and pathogens. Understanding how exosomes mediate these different interactions has the potential to advance immune-based therapies for a range of disorders, including autoimmune diseases, cancers, and infectious diseases. Therefore, this research topic on "Exosome-Mediated Intercellular Communications: Immune Stimulation and Suppression" aims to explore the mechanisms behind these processes and how exosomes could potentially be utilized as therapeutic agents.

One of the primary goals of this Research Topic is to investigate the composition and functions of exosomes released by different immune cell subsets and determine the targets of these immunomodulatory exosomes. This topic also aims to gain a deeper understanding of the mechanisms that underlie immune stimulation and suppression by exosomes and their interactions with various immune cells. Moreover, this Research Topic seeks to evaluate the feasibility and safety of exosomes as clinical therapeutics and examine their potential for a range of disorders, including autoimmune diseases, cancers, and infectious diseases. Ultimately, the goal of this topic is to contribute to a better understanding of the immune system and the role of exosomes in regulating immune responses, thereby enabling the development of novel diagnostic and therapeutic approaches to various diseases.

This Research Topic accepts Original Research, Review and Mini-Review articles. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Characterizing exosomes released by different immune-cell subsets
• Determining the cellular targets of immune-modulatory exosomes
• Investigating the mechanisms governing exosome-mediated immune stimulation and suppression
• Exploring the potential of exosomes as therapeutic agents
• Developing new diagnostic and prognostic tools for various diseases
• Evaluating the effectiveness and safety of exosomes in clinical settings
• Investigating the roles of exosomes in immune tolerance and autoimmune disorders
• Elucidating the interactions between immune cells and microbiota through exosome-mediated communication
• Identifying exosome-based biomarkers for disease detection and monitoring
• Understanding how exosomes can be engineered for specific therapeutic applications.