About this Research Topic

Background

Dental pulp disease encompasses a spectrum of conditions ranging from reversible pulpitis to necrotic pulp, with or without pulp exposure, and the development of apical pathology. Upon diagnosis, clinical treatment strategies should consider multiple factors including pulp vitality with remaining sound pulp tissue, tooth structure restorability, and longevity of the selective biomaterials. Although conventional treatments such as direct/indirect dental pulp capping, pulpotomy, and pulpectomy have been widely used and shown significant clinical and radiographic achievements, the restoration and regeneration of pulp tissue have remained a challenging aspect in endodontics for several years. Therefore, it is essential to continuously innovate treatment approaches including biomaterials, methods, and outcome measures for pulp treatments.

Regenerating dental pulp tissue presents several clinical hurdles and problems that clinical investigators across the globe are actively addressing. Some of them are limited availability of suitable cell sources, heterogeneity and complexity of the existing pulpal tissue, establishment of a functional vasculature, ideal scaffold selection and optimization, innervation, and sensory function and finally, clinical translation and standardization pose a major hurdle. To overcome these issues robust in vitro and in vivo studies that are investigating conventional pulp treatment outcomes and suggesting innovative approaches to pulp regeneration using novel biomaterials and therapeutic techniques may lead to a paradigm shift in research to give insights into the possible next generation of innovations in dental pulp treatment and regenerative approaches.
The objective of this translational Research Topic is to summarize current and conventional pulp treatment outcomes and suggest innovative approaches to pulp regeneration using novel materials and techniques.

The scope of this Research Topic is to highlight cutting-edge progress in biomaterials and their clinical application to regenerative dentistry. The editors anticipate that this article collection will offer translational researchers and clinicians valuable insights into the design of pulp tissue engineering strategies and facilitate the clinical translation of these approaches. Here are some topics of interest:

• Dentin and pulp interface inflammation and healing
• Pulp tissue regeneration
• Current dental pulp capping materials
• Current pulp regenerative techniques
• Innovations in regenerative endodontic procedure
• Stem cell/growth factor/scaffold-based approaches
• Clinical trials

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Curriculum, Instruction, and Pedagogy
• Data Report
• Editorial
• General Commentary
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Curriculum, Instruction, and Pedagogy
• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Policy Brief
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Pulp treatment outcomes, Innovations in pulp treatment materials, Innovations in pulp treatment techniques, Pulp tissue healing, Pulp tissue regeneration, Biomaterials for pulp regeneration, Tissue repair in endodontics, Pulp dentine complex preservation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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