About this Research Topic
Antimicrobial resistance (AMR) is still one of the most difficult concerns threatening human’s health across the world and represents one of the top ten worldwide public health challenges confronting humanity according to World Health Organization. Consequently, the economic burden of AMR is substantial. In fact, long-term disease not only increases the risk of mortality and incapacity but also lengthens hospital stays, necessitates the use of more expensive medications, and puts a strain on the finances of those affected.
Without efficient antimicrobials, infections would be more difficult to treat in modern medicine, notably for immunocompromised patients. Numerous lines of research are developed into new classes of molecules aimed at new "targets" of action in bacteria, in order to circumvent bacterial resistance mechanisms. The aim of this Research Topic is to investigate the effect of new anti-infection agents from natural (such as essential oils, major compounds, plan extract) or chemical resources, against drug resistant pathogenic bacteria, as-well as exploration of their different mode of actions and competitive effects.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Synthesis and characterization of new active compounds
• Chemical composition analysis of natural bioactive substances
• Anti-virulence and anti-quorum sensing activities of active substances (molecules)
• Induction of oxidative stress in bacterial cells (generation of reactive oxygen species ROS, lipoperoxidation…) in treated cells
• Effect in macromolecules (DNA, Lipids…) and bacterial cell membrane
Without efficient antimicrobials, infections would be more difficult to treat in modern medicine, notably for immunocompromised patients. Numerous lines of research are developed into new classes of molecules aimed at new "targets" of action in bacteria, in order to circumvent bacterial resistance mechanisms. The aim of this Research Topic is to investigate the effect of new anti-infection agents from natural (such as essential oils, major compounds, plan extract) or chemical resources, against drug resistant pathogenic bacteria, as-well as exploration of their different mode of actions and competitive effects.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Synthesis and characterization of new active compounds
• Chemical composition analysis of natural bioactive substances
• Anti-virulence and anti-quorum sensing activities of active substances (molecules)
• Induction of oxidative stress in bacterial cells (generation of reactive oxygen species ROS, lipoperoxidation…) in treated cells
• Effect in macromolecules (DNA, Lipids…) and bacterial cell membrane
Keywords: Active substances, Chemical characterization, Antibacterial effects, Mode of action
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
