About this Research Topic
Non-invasive brain stimulation (NIBS) is a rapidly expanding field of neuropsychiatric research and clinical practice. New diagnostic and therapeutic tools have emerged to query and modulate brain circuits relevant in both health and disease.
Transcranial magnetic simulation (TMS) and transcranial electrical stimulation are the most widely used NIBS modalities in neuropsychiatric research and treatment, albeit with limitations. Another upcoming modality - low intensity focused ultrasound (LIFU), also holds great promise as a novel approach to non-invasive brain stimulation which may be able to directly modulate activity within deeper brain structures with high spatial precision.
Additional research on the diagnostic and therapeutic uses of non-invasive brain stimulation in humans, and how NIBS can be used to further our understanding of neurophysiology in both the healthy and disease states, is desirable. Addressing this unmet need would inform the design of brain stimulation protocols for diagnostic, predictive, target engagement, and treatment indications.
The therapeutic effects of brain stimulation, particularly cortical stimulation, are reliant on mechanisms of neuronal excitability and neuronal plasticity. Insight into such mechanisms at the synaptic and molecular levels has come largely from animal models. While important aspects of neurobiology, such as the maturational patterns of γ-aminobutyric acid (GABA)-mediated inhibition, glutamate-mediated excitation, and use-dependent synaptic plasticity, and their dysfunction in neurological disease are well described, these are largely derived from in-vitro and ex-vivo experiments in animals, rather than from non-invasive brain stimulation protocols.
This Research Topic aims to provide a better understanding of how non-invasive brain stimulation (NIBS) can be use to study underlying network physiology and how it matures during development in both healthy and disease states, and bring together new perspectives on the clinical utility of NIBS in the diagnosis, prognosis, and treatment of neurological and psychiatric conditions.
We welcome submissions of original research, brief research reports, reviews, and case reports focusing on NIBS-derived metrics of neurodevelopmental processes both in healthy and disease states, as well as the development and use of NIBS-derived markers of therapeutic target engagement in neurological and psychiatric disease including, but not limited to, epilepsy, traumatic brain injury, cognitive dysfunction, and addiction. We also encourage and welcome any translational research that would aid in elucidating the mechanisms of NIBS.
Transcranial magnetic simulation (TMS) and transcranial electrical stimulation are the most widely used NIBS modalities in neuropsychiatric research and treatment, albeit with limitations. Another upcoming modality - low intensity focused ultrasound (LIFU), also holds great promise as a novel approach to non-invasive brain stimulation which may be able to directly modulate activity within deeper brain structures with high spatial precision.
Additional research on the diagnostic and therapeutic uses of non-invasive brain stimulation in humans, and how NIBS can be used to further our understanding of neurophysiology in both the healthy and disease states, is desirable. Addressing this unmet need would inform the design of brain stimulation protocols for diagnostic, predictive, target engagement, and treatment indications.
The therapeutic effects of brain stimulation, particularly cortical stimulation, are reliant on mechanisms of neuronal excitability and neuronal plasticity. Insight into such mechanisms at the synaptic and molecular levels has come largely from animal models. While important aspects of neurobiology, such as the maturational patterns of γ-aminobutyric acid (GABA)-mediated inhibition, glutamate-mediated excitation, and use-dependent synaptic plasticity, and their dysfunction in neurological disease are well described, these are largely derived from in-vitro and ex-vivo experiments in animals, rather than from non-invasive brain stimulation protocols.
This Research Topic aims to provide a better understanding of how non-invasive brain stimulation (NIBS) can be use to study underlying network physiology and how it matures during development in both healthy and disease states, and bring together new perspectives on the clinical utility of NIBS in the diagnosis, prognosis, and treatment of neurological and psychiatric conditions.
We welcome submissions of original research, brief research reports, reviews, and case reports focusing on NIBS-derived metrics of neurodevelopmental processes both in healthy and disease states, as well as the development and use of NIBS-derived markers of therapeutic target engagement in neurological and psychiatric disease including, but not limited to, epilepsy, traumatic brain injury, cognitive dysfunction, and addiction. We also encourage and welcome any translational research that would aid in elucidating the mechanisms of NIBS.
Keywords: Non-invasive brain stimulation, Transcranial magnetic simulation, Transcranial electrical stimulation, Low intensity focused ultrasound, Neurodevelopmental processes
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