About this Research Topic
Immune metabolism has emerged as a new research area in immunology. Metabolic programs broadly specify many facets of auto- and allo-immune responses. Metabolic pathways and their associated metabolites have become increasingly better defined using contemporary -omics approaches which have uncovered causal connections between metabolites and key processes associated with immune cell differentiation and terminal effector functioning. Such intersections have been explored in the setting of auto- and allo-immunity. Due to its inherent clinical implications, how immune metabolism modulates auto- and allo-immunity is of great current interest to the field.
Immune metabolism broadly governs many facets of auto- and allo-immune disease. A key problem area relevant to this topic is linking specific metabolic pathway(s) or associated metabolite(s) to one or more immune responses relevant to disease. Immune processes of interest include differentiation, effector polarization, migratory homing, survival, and contraction. Of additional interest is how metabolic processes regulate the gut microbiome and immune metabolism of cells in peripheral tissues known to regulate immune responses including CNS glial cells, synoviocytes, pericytes, endothelial cells, and epithelial cells. This Research Topic aims to explore both innate and adaptive immunity, considering submissions of prevalent or rare disease conditions involving auto- or allo-immunity. We also welcome clinical, translational, and preclinical studies in order to obtain a comprehensive view of contemporary basic research and how these findings translate to patient care in auto- and allo-immunity.
Submissions approaching these problem areas using large-scale -omics approaches, biochemical studies, and in vivo disease models are of interest. We are interested in Clinical Trial, Review/Mini-review, Systematic Review, Original Research, and Technology and Code articles, focusing on but not limited to the following areas:
• Immune metabolism and gut microbiota
• Immune metabolism in peripheral tissues as above including resident immune and parenchymal cells
• Large-scale -omics approaches for immune metabolism
• Mechanistic studies for immune metabolism in innate cells
• Mechanistic studies for immune metabolism in adaptive immunity
Immune metabolism broadly governs many facets of auto- and allo-immune disease. A key problem area relevant to this topic is linking specific metabolic pathway(s) or associated metabolite(s) to one or more immune responses relevant to disease. Immune processes of interest include differentiation, effector polarization, migratory homing, survival, and contraction. Of additional interest is how metabolic processes regulate the gut microbiome and immune metabolism of cells in peripheral tissues known to regulate immune responses including CNS glial cells, synoviocytes, pericytes, endothelial cells, and epithelial cells. This Research Topic aims to explore both innate and adaptive immunity, considering submissions of prevalent or rare disease conditions involving auto- or allo-immunity. We also welcome clinical, translational, and preclinical studies in order to obtain a comprehensive view of contemporary basic research and how these findings translate to patient care in auto- and allo-immunity.
Submissions approaching these problem areas using large-scale -omics approaches, biochemical studies, and in vivo disease models are of interest. We are interested in Clinical Trial, Review/Mini-review, Systematic Review, Original Research, and Technology and Code articles, focusing on but not limited to the following areas:
• Immune metabolism and gut microbiota
• Immune metabolism in peripheral tissues as above including resident immune and parenchymal cells
• Large-scale -omics approaches for immune metabolism
• Mechanistic studies for immune metabolism in innate cells
• Mechanistic studies for immune metabolism in adaptive immunity
Keywords: Autoimmunity, alloimmunity, immune metabolism, metabolite, energetics, gut microbiota, innate cells, adaptive immunity, innate immunity, omics
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