Recent Advances in Diagnosis and Treatment of Brain Tumors: From Pediatrics to Adults

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Background

In the last few years, an impressive development has been achieved in the arena of new diagnostic and therapeutic approaches for brain tumors, both in children and adults. This has in turn led to the recognition of new tumour entities as well as to better categorization of the existing ones. The recent WHO classification of the CNS tumors (2021) has been entirely revised and the term “integrated diagnosis” has been since then applied, which refers to a combination of the classical histopathological diagnosis with the accompanying molecular results of some of the most common tumors. In addition, a lot of progress has been made in the field of imaging, with the invention of more accurate methods and the improvement of previously established diagnostic modalities. As a result of the aforementioned achievements in the diagnosis of brain tumors, new treatment options have been introduced, which respond more successfully to the handling of the several tumor entities.

Due to the immense progress not only in the field of diagnosis but also in the treatment of brain tumors, it is of utmost importance to present the newly identified biomarkers and innovative techniques, which allow on the one hand a more accurate diagnosis and on the other hand a more precise therapeutic intervention. Since a lot of research is conducted at present with this regard, the result of these investigations should be shared with the broader research community, in order to improve thereafter both the available diagnostic methods in the fields of histopathology and imaging and the therapeutic techniques in the areas of neurosurgery and chemo-/radiotherapy. Undoubtfully, this will contribute substantially in the accomplishment of the target of “personalized medicine” in the public.

The current Research Topic aims to bring together new discoveries in the diagnosis and therapy of pediatric and adult brain tumors. In this context there is an open invitation to all the researchers and clinicians who are involved in this area, to participate actively by contributing their valuable results and experiences with research focused on primary brain tumors. Moving towards our actual goal as medical society, which is not other than the implementation of “personalized medicine”, our actual topic could be of particular value in the accomplishment of some of its fundamentals, namely i. precise diagnosis, ii. personalized intervention, iii. patient’s participation, iv. prediction and prevention of the disease and v. supportive care/ neurorehabilitation. Manuscripts that are primarily in silico/bioinformatics based, including prognostic algorithms using large databases, and do not have sufficient validation in an independent cohort of patients from one or more institutions (rather than using another database) and/or functional validation in at least two acceptable tumor cell lines in vitro/in vivo, will not be considered

Keywords: Integrated diagnosis, biomarkers, histopathology, molecular biology, imaging investigations, neurosurgical procedures, chemotherapy, radiotherapy gliomas, pharmacokinetics, drug delivery

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