About this Research Topic
The coronavirus disease 2019 (COVID-19) pandemic has deteriorated healthcare systems and interfered with established treatment concepts. There is an emerging need for research and understanding of inflammatory pathways contributing to endothelial dysfunction and prothrombotic states during severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infections. The disease disturbs the subtle equilibrium between platelet-platelet and platelet-vessel wall interactions influencing all components of the Virchow’s triad. The overlapping limbs of Virchow’s triad include hypercoagulation in different organs like the lungs, heart and brain.
Moreover, viral persistence and possibly also viral reactivation resembles processes of acute infection, emerging as another challenging therapeutic aspect.
The following Research Topic welcomes original articles, reviews, opinion papers, and case reports regarding thromboinflammatory pathways during acute and long COVID with a special focus on cardiovascular and respiratory diseases. Pathomechanisms during (long) COVID often resemble hitherto known pathways of thromboinflammation in cardiovascular and respiratory diseases. However, distinct differences can be observed and should be addressed in this Research Topic:
• Thromboinflammation in acute and long COVID
• Pathways of thromboinflammation in cardiovascular and respiratory diseases
• Role of thromboinflammation in post COVID sequelae/ viral persistence
• Role of the immune system in platelet reactivity during long COVID
• Immune mechanisms in vascular diseases as a consequence of COVID-19
Topic Editor Dr. Mariann Gyongyosi has a postdoctoral project supported by the Austrian Science Fund, and the Bürgermeisterfond der Stadt Wien. The other Topic Editors declare no competing interests with regard to the Research Topic subject
Moreover, viral persistence and possibly also viral reactivation resembles processes of acute infection, emerging as another challenging therapeutic aspect.
The following Research Topic welcomes original articles, reviews, opinion papers, and case reports regarding thromboinflammatory pathways during acute and long COVID with a special focus on cardiovascular and respiratory diseases. Pathomechanisms during (long) COVID often resemble hitherto known pathways of thromboinflammation in cardiovascular and respiratory diseases. However, distinct differences can be observed and should be addressed in this Research Topic:
• Thromboinflammation in acute and long COVID
• Pathways of thromboinflammation in cardiovascular and respiratory diseases
• Role of thromboinflammation in post COVID sequelae/ viral persistence
• Role of the immune system in platelet reactivity during long COVID
• Immune mechanisms in vascular diseases as a consequence of COVID-19
Topic Editor Dr. Mariann Gyongyosi has a postdoctoral project supported by the Austrian Science Fund, and the Bürgermeisterfond der Stadt Wien. The other Topic Editors declare no competing interests with regard to the Research Topic subject
Keywords: SARS-CoV-2, Long COVID, thromboinflammation, respiratory diseases, cardiovascular diseases, platelet reactivity, leukocyte activation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
