About this Research Topic

Background

More and more evidence has demonstrated that gut microbiome plays critical roles in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis.

The new conception ‘gut-skin axis’ refers to the bidirectional relationship between the gut microbiome and skin health. Several mechanisms, such as intestinal barrier, inflammatory mediators, and metabolites, have been proposed for gut-skin axis. Currently, there have been various studies regarding the presence of the gut-skin axis and its resulting inflammatory effect due to gut microbiome imbalance. In addition, dysbiosis of the skin and gut microbiota is also observed in skin disorders. Therefore, understanding the gut-skin axis, especially in terms of microbiome modulation, is important for the gut and skin health, which may lead to development of novel therapies for skin disease.

The gastrointestinal (GI) tract is one of the largest interfaces between the host and its environment, and is colonized by a large number of microbes, which have a big impact on host health. The skin epidermis, with appendage structures, such as sweat and sebaceous glands, have a total skin surface of about 25 m 2 and is one of the largest epithelial surfaces for interaction with microbes. Moreover, both gut and skin act as barriers for immune function. Recent multi-omics technological advances have revealed the importance of the microbiome in health and diseases. Thus, deep investigation of the roles of the microbiome in skin disease will contribute to unveil the mechanisms of the gut-skin axis. In addition, it is necessary to better characterize the skin microbiota and its modes of interaction with the host’s immune system.

In this Research Topic, we explore the mechanisms of gut-skin axis providing new contributions to increase knowledge to prevent or treat common skin diseases through
modulating the gut microbiome.

This Research Topic welcomes various subjects of interest, including but not limited to the following:
• The mechanism of gut-skin axis.
• Modulating the gut microbiome to improve skin disease.
• Isolation and characterization of species from the gut, skin, and their roles in host health.
• Assessing the roles of key skin microbial members and their impact on host immune functions.

Keywords: Gut-Skin Axis, Microbiome, Skin Disease, Skin Epidermis, Gut Microbiome, Microbiome-Dynamics

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