About this Research Topic
Maintaining the balance of water, electrolytes and solutes is an essential physiological function for survival. It refers to the body's ability to regulate water intake and clearance, but also the active renal elimination and reabsorption of solutes such as salts, glucose and urea.
The balance between plasma and urine osmolality is the prerogative of the antidiuretic system, represented by the arginine-vasopressin (AVP) produced by the hypothalamus. However, many other endocrine factors such as the renin-angiotensin-aldosterone system, natriuretic peptides, but also gastrointestinal hormones, modulate both AVP secretion and its peripheral activities, also regulating organic salts and solutes reabsorption in the kidney.
Among water and electrolyte disorders, both diabetes insipidus and hypotonic hyponatremia have recently gained increasing scientific interest, thanks to the proposal of new diagnostic approaches and therapeutic advances. However, we still need accurate, yet handy, non-osmotic stimuli for AVP release, reliable assessments of extracellular fluid volume and sodium content, direct comparisons of the efficacy of organic solutes versus other therapeutic approaches for the treatment of hypotonic hyponatremia.
This Research Topic aims to gather new evidence in the pathophysiology of AVP, as well as in the management of water and electrolyte disturbances due to AVP deficiency, resistance, or impaired regulation. In particular, the research topic aims to deepen the pathophysiological understanding of both the conditions of hyperhydration or dehydration, and the balance of organic solutes, for a correct diagnostic-therapeutic approach to the extracellular fluid disorders.
This Research Topic will include original research articles, reviews and meta-analysis on the following themes:
- Secretion, peripheral action and regulation of AVP
- Water and electrolyte disorders (such as syndrome of inappropriate antidiuresis and other causes of hypotonic hyponatremia, diabetes insipidus and other causes of hypernatremia)
- Evaluation of extracellular fluid volume, as well as new insight in the pathophysiology of dehydration and hyperhydration
- Regulation of the balance of organic solutes and their therapeutic application in hydro-electrolyte disorders
The balance between plasma and urine osmolality is the prerogative of the antidiuretic system, represented by the arginine-vasopressin (AVP) produced by the hypothalamus. However, many other endocrine factors such as the renin-angiotensin-aldosterone system, natriuretic peptides, but also gastrointestinal hormones, modulate both AVP secretion and its peripheral activities, also regulating organic salts and solutes reabsorption in the kidney.
Among water and electrolyte disorders, both diabetes insipidus and hypotonic hyponatremia have recently gained increasing scientific interest, thanks to the proposal of new diagnostic approaches and therapeutic advances. However, we still need accurate, yet handy, non-osmotic stimuli for AVP release, reliable assessments of extracellular fluid volume and sodium content, direct comparisons of the efficacy of organic solutes versus other therapeutic approaches for the treatment of hypotonic hyponatremia.
This Research Topic aims to gather new evidence in the pathophysiology of AVP, as well as in the management of water and electrolyte disturbances due to AVP deficiency, resistance, or impaired regulation. In particular, the research topic aims to deepen the pathophysiological understanding of both the conditions of hyperhydration or dehydration, and the balance of organic solutes, for a correct diagnostic-therapeutic approach to the extracellular fluid disorders.
This Research Topic will include original research articles, reviews and meta-analysis on the following themes:
- Secretion, peripheral action and regulation of AVP
- Water and electrolyte disorders (such as syndrome of inappropriate antidiuresis and other causes of hypotonic hyponatremia, diabetes insipidus and other causes of hypernatremia)
- Evaluation of extracellular fluid volume, as well as new insight in the pathophysiology of dehydration and hyperhydration
- Regulation of the balance of organic solutes and their therapeutic application in hydro-electrolyte disorders
Keywords: Arginine-vasopressin, extracellular fluid volume, urea, glucose metabolism, hypotonic hyponatremia, diabetes insipidus
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
