Differential Diagnosis of Erythrocytosis and Analysis of Their Clinical Utility

Erythrocytosis frequently represents a challenge for the treating doctors. Primary erythrocytosis are caused by acquired or inherited mutations leading to the functional changes within hematopoietic stem cells or erythroid progenitors and excess proliferation of red cells. The most common primary erythrocytosis, is polycythemia vera, which is a clonal acquired disorder. The other primary erythrocytosis is inherited related to the mutations in erythropoietin receptor. In contrast, secondary erythrocytosis which also can be acquired or hereditary but the more often are acquired caused by hypoxemia or result of elevated levels of erythropoietin (cancer-associated production). Although the clinical presentations of primary and secondary erythrocytosis may be similar, distinguishing among them is important for accurate diagnoses and proper management.

Therefore, the main goal of this Research Topic is to analysis of different causes of erythrocytosis with an assessment of their influence on the development of thrombosis and survival. Proposal of further prevention measures according to the obtained results.

Also, we aim to analyse the frequency of different types of erythrocytosis and their correlation with clinical laboratory characteristics. Assessment the impact of the causes of erythrocytosis (congenital, familial, secondary etc) on the development of complications and survival. Frequency and types of molecular markers associated with the development of erythrocytosis.

This Research Topic welcomes the following article types: Brief Research Report, Case Report, Clinical Trial, Correction, Editorial, General Commentary, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, Systematic Review.