About this Research Topic
Three important neglected diseases are caused by Trypanosomatidae: leishmaniasis, human African sleeping sickness (HAT) and Chagas disease. Among them, there are more than 7 million infected people around the world causing significant public health burden. These diseases are not easily be eradicated since reservoir animals are able to maintain the parasites independently as a source of zoonotic infection. Scientific advances have focused on early diagnostics, vaccines, treatments, and vector control. Here, this research topic aims to compile the most recent advances in immunological biomarkers that can support a greater understanding of host immune responses to leishmaniasis, human African sleeping sickness (HAT) and Chagas disease. In particular, the research topic focuses on immunological biomarkers which may aid in early diagnosis, diagnosis differentiation, prophylaxis and vaccinology. This can further consolidate current knowledge and facilitate the progress towards the elimination of these neglected tropical diseases.
This Research Topic accepts Original Research, Systematic Review, Methods, Review, Clinical Trial, Perspective. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• host immune responses to Trypanossomatidae
• immunological biomarkers in Trypanossomatidae diseases (mainly human) for early diagnosis and diagnosis differentiation
• Immunological biomarkers in Trypanossomatidae diseases (mainly human) for prophylaxis, including One health
• Immunological biomarkers in Trypanossomatidae diseases (mainly human) for vaccinology
• Immunological biomarkers in Trypanossomatidae diseases (mainly human) for immune competence and mechanisms of parasite survival
The Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Leishmania, Chagas, Trypanosomatidae, biomarkers, protection, vaccine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.