About this Research Topic
The increasing aged population has become an urgent issue worldwide. During the aging process, organisms undergo dysregulated inflammation, cellular senescence, and reduced regenerative capacity, which can result in a variety of health conditions. The prevalence of age-related diseases (ARDs) like Alzheimer's disease, Parkinson's disease, cardiovascular disease, and chronic kidney diseases are anticipated to augment considerable strain on the healthcare system. Furthermore, a greater number of elderly people necessitates more long-term care, which will result in increased economic and mental burdens for the whole society.
Research into aging and healthy aging such as exploring the roles and interplays of epigenetic regulatory elements including DNA methylation, m6A, and noncoding RNA during the aging process is crucial for understanding how we age and is useful for developing interventions that could delay or prevent ARDs; however, it remains challenging due to the lack of stabilized and broadly applicable models. Therefore, it is essential to develop novel and robust models to elucidate a better understanding of the molecular mechanisms behind aging, healthy aging, and ARDs.
This Research Topic aims to assemble a series of articles that address the current understanding of the underlying mechanisms of aging and the healthy aging process. Subtopics may include, but are not limited to:
1. Development of new models or strategies for aging, healthy aging, and ARDs studies.
2. Explore the function or trajectory of epigenetic regulatory elements during aging using multi-omics techniques.
3. Investigate the molecular mechanisms of aging-related genes by experimental assays.
Research into aging and healthy aging such as exploring the roles and interplays of epigenetic regulatory elements including DNA methylation, m6A, and noncoding RNA during the aging process is crucial for understanding how we age and is useful for developing interventions that could delay or prevent ARDs; however, it remains challenging due to the lack of stabilized and broadly applicable models. Therefore, it is essential to develop novel and robust models to elucidate a better understanding of the molecular mechanisms behind aging, healthy aging, and ARDs.
This Research Topic aims to assemble a series of articles that address the current understanding of the underlying mechanisms of aging and the healthy aging process. Subtopics may include, but are not limited to:
1. Development of new models or strategies for aging, healthy aging, and ARDs studies.
2. Explore the function or trajectory of epigenetic regulatory elements during aging using multi-omics techniques.
3. Investigate the molecular mechanisms of aging-related genes by experimental assays.
Keywords: Novel models, Epigenetic regulatory elements, aging, aging-related diseases, healthy aging
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