About this Research Topic
Maintaining immune homeostasis at the gut barrier relies on multiple cellular crosstalk mechanisms. Failure in these mechanisms is believed to be the underlying cause of chronic idiopathic and acute infectious inflammatory conditions that affect the gut. These cell-cell interactions ensure appropriate responses in the gut ecosystem, which is abundant in microbiota. In addition, they coordinate the renewal of the epithelium and immune deactivation once environmental threats are neutralized.
Recent developments have shed light on the potential roles of enteric glia in regulating gut immune homeostasis and barrier function. Exciting insights have emerged in the past decade, revealing the diverse functions of enteric glia in regulating macrophage, T-cell, nervous, and epithelial processes. Furthermore, identifying various transcriptomically defined subsets of enteric glia has paralleled these discoveries. Consequently, enteric glia are no longer considered mere bystanders of the enteric nervous system, as they were once believed to be.
This Research Topic focuses on compiling newly discovered molecular insights that govern the interactions between enteric glial cell and other cell populations within the intestines, including immune cells, parenchymal cells, and stromal cells. We invite original research articles, reviews, and brief reports that shed light on the functions of enteric glial cells in preserving intestinal immunity, promoting gut barrier function, and maintaining overall homeostasis.
We welcome submissions employing various biological approaches, such as in vivo and in vitro experiments, as well as cellular, genetic, and molecular investigations, to explore the fascinating field of enteric glial cell immunobiology in relation to intestinal diseases. Specifically, we encourage research on the following topics:
• Enteric glia and immune cell communication in the context of intestinal inflammatory conditions.
• Enteric glia and enteric nervous system interplay with stromal cells during gut inflammation.
• Enteric glia and their role in maintaining intestinal epithelial homeostasis during inflammatory conditions.
• Enteric glia and their role in intestinal motility during inflammatory diseases.
We look forward to receiving contributions that shed light on these important aspects of enteric glial cell biology and their involvement in intestinal diseases.
Recent developments have shed light on the potential roles of enteric glia in regulating gut immune homeostasis and barrier function. Exciting insights have emerged in the past decade, revealing the diverse functions of enteric glia in regulating macrophage, T-cell, nervous, and epithelial processes. Furthermore, identifying various transcriptomically defined subsets of enteric glia has paralleled these discoveries. Consequently, enteric glia are no longer considered mere bystanders of the enteric nervous system, as they were once believed to be.
This Research Topic focuses on compiling newly discovered molecular insights that govern the interactions between enteric glial cell and other cell populations within the intestines, including immune cells, parenchymal cells, and stromal cells. We invite original research articles, reviews, and brief reports that shed light on the functions of enteric glial cells in preserving intestinal immunity, promoting gut barrier function, and maintaining overall homeostasis.
We welcome submissions employing various biological approaches, such as in vivo and in vitro experiments, as well as cellular, genetic, and molecular investigations, to explore the fascinating field of enteric glial cell immunobiology in relation to intestinal diseases. Specifically, we encourage research on the following topics:
• Enteric glia and immune cell communication in the context of intestinal inflammatory conditions.
• Enteric glia and enteric nervous system interplay with stromal cells during gut inflammation.
• Enteric glia and their role in maintaining intestinal epithelial homeostasis during inflammatory conditions.
• Enteric glia and their role in intestinal motility during inflammatory diseases.
We look forward to receiving contributions that shed light on these important aspects of enteric glial cell biology and their involvement in intestinal diseases.
Keywords: Enteric glial cells, intestinal immunity, neuro-immune axis, enteric nervous system in immunity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
