With the development of gene technology, especially bone-specific gene knockout technology, the functions of bone have been uncovered gradually. Bone is a living and dynamic organ, which coordinately processes the role of bone formation by osteoblasts and bone resorption by osteoclasts. Besides osteoblasts ...
With the development of gene technology, especially bone-specific gene knockout technology, the functions of bone have been uncovered gradually. Bone is a living and dynamic organ, which coordinately processes the role of bone formation by osteoblasts and bone resorption by osteoclasts. Besides osteoblasts and osteoclasts, there is another important type of bone cell called osteocytes, which comprises 95% of bone cells and regulates osteoclasts and osteoblasts to maintain bone homeostasis. Bones do not only contain the widely known calcium, phosphonate, and collagen, but also some unknown bioactive molecules. Moreover, bone also reveals extra-skeletal functions and is redefined as an active endocrine organ, which suggests its correlation with other organs. Accumulating evidence about the relationship between bone and other organ has been unveiled, including the “bone-brain” axis, “bone-gut” axis, “bone-blood vessel” axis and “bone-muscle” axis. Bone‐derived factors (such as osteocalcin, sclerostin and RANKL) do not only participate in the maintenance bone homeostasis, but also in the systemic balance of the entire body, including the development of brain and muscle. These also suggest that the integrative physiology would be a popular topic in future research.
This Research Topic will be mainly focused on new insights in the communication and relationship between bone and the whole body, and the new mechanistic findings on the roles of bone‐derived factors in bone or other organ-related diseases. In this Research Topic, we welcome original research articles and reviews that include but not limited to, the following sub-topics:
- Medical big data analysis, imaging genomics, radiomics, proteomics, metabolomics intelligent early diagnosis, scientometrics, and multiomics analysis of key genes in the regulation of bone-derived factors
- Impact of bone cells and the bone-derived factors on other organs and diseases
- Molecular mechanisms and the new functions of bone‐derived factors in bone diseases
- Crosstalk between bone and other organs
- Advanced theory to guide treatment, prognosis and validation of bone-related diseases
Keywords:
bone, bone disease, bone-derived factors
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.