About this Research Topic
The goal of this Research Topic is to provide a platform for researchers to showcase their latest findings and insights into the exciting and rapidly evolving field of oxytosis/ferroptosis. Recent studies have highlighted the contribution of oxytosis/ferroptosis to the pathogenesis of a broad range of neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, making it an attractive therapeutic target. In this Research Topic, we aim to cover the latest advancements in understanding the mechanisms underlying oxytosis/ferroptosis, its contribution to neurodegeneration, and the search for effective therapeutic strategies. Submissions in the form of original research articles, reviews, and perspectives on topics related to oxytosis/ferroptosis, include but are not limited to:
1. Iron homeostasis and Lipid Peroxidation: Iron homeostasis and lipid peroxidation are critical mechanisms underlying the initiation and execution of oxytosis/ferroptosis. We aim to cover the latest discoveries in the intricate interplay between oxidative stress, iron regulation, and lipid peroxidation and their contributions to the pathogenesis of neurodegenerative disorders.
2. From Alzheimer's to Huntington's: A focus on oxytosis/ferroptosis in different neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, and how this non-apoptotic, regulated cell death pathway may have distinct contributions to disease pathogenesis. We will also cover the use of animal and cellular models to investigate the role of oxytosis/ferroptosis in neurodegeneration.
3. The Hunt for Neuroprotective Agents: A focus on discussing recent advances in identifying and developing neuroprotective agents targeting oxytosis/ferroptosis for disease modification and prevention. This theme will also cover the challenges and opportunities in translating these findings to the clinic.
4. Tools and Technologies to Study Oxytosis/Ferroptosis: We aim to cover the latest tools and technologies available to study oxytosis/ferroptosis, including omics approaches, imaging, and electrophysiology. Additionally, examples of how these approaches can be used to identify novel therapeutic targets and biomarkers of oxytosis/ferroptosis-mediated neurodegeneration.
5. Role of Glial cells in oxytosis/ferroptosis: Glial cells, such as astrocytes and microglia, have emerged as key players in modulating oxytosis/ferroptosis in the nervous system. Dysregulation of iron metabolism and the accumulation of excess iron have been linked to the initiation and execution of oxytosis/ferroptosis. Astrocytes play an important role in maintaining iron homeostasis in the brain by regulating the expression and activity of iron transporters and storage proteins, such as transferrin and ferritin. This regulation helps prevent excess iron accumulation, which can trigger oxytosis/ferroptosis. Therefore, studying the complex interplay between glial cells and oxytosis/ferroptosis is crucial for developing effective therapeutic strategies for neurodegenerative diseases.
By bringing together a diverse range of studies and perspectives, we hope to advance our knowledge and stimulate further scientific research and discussions that will further our understanding of oxytosis/ferroptosis in neurodegeneration and accelerate the development of effective therapeutic interventions.
1. Iron homeostasis and Lipid Peroxidation: Iron homeostasis and lipid peroxidation are critical mechanisms underlying the initiation and execution of oxytosis/ferroptosis. We aim to cover the latest discoveries in the intricate interplay between oxidative stress, iron regulation, and lipid peroxidation and their contributions to the pathogenesis of neurodegenerative disorders.
2. From Alzheimer's to Huntington's: A focus on oxytosis/ferroptosis in different neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, and how this non-apoptotic, regulated cell death pathway may have distinct contributions to disease pathogenesis. We will also cover the use of animal and cellular models to investigate the role of oxytosis/ferroptosis in neurodegeneration.
3. The Hunt for Neuroprotective Agents: A focus on discussing recent advances in identifying and developing neuroprotective agents targeting oxytosis/ferroptosis for disease modification and prevention. This theme will also cover the challenges and opportunities in translating these findings to the clinic.
4. Tools and Technologies to Study Oxytosis/Ferroptosis: We aim to cover the latest tools and technologies available to study oxytosis/ferroptosis, including omics approaches, imaging, and electrophysiology. Additionally, examples of how these approaches can be used to identify novel therapeutic targets and biomarkers of oxytosis/ferroptosis-mediated neurodegeneration.
5. Role of Glial cells in oxytosis/ferroptosis: Glial cells, such as astrocytes and microglia, have emerged as key players in modulating oxytosis/ferroptosis in the nervous system. Dysregulation of iron metabolism and the accumulation of excess iron have been linked to the initiation and execution of oxytosis/ferroptosis. Astrocytes play an important role in maintaining iron homeostasis in the brain by regulating the expression and activity of iron transporters and storage proteins, such as transferrin and ferritin. This regulation helps prevent excess iron accumulation, which can trigger oxytosis/ferroptosis. Therefore, studying the complex interplay between glial cells and oxytosis/ferroptosis is crucial for developing effective therapeutic strategies for neurodegenerative diseases.
By bringing together a diverse range of studies and perspectives, we hope to advance our knowledge and stimulate further scientific research and discussions that will further our understanding of oxytosis/ferroptosis in neurodegeneration and accelerate the development of effective therapeutic interventions.
Keywords: oxytosis, ferroptosis, neurodegenerative disease
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