Frontiers | Leishmaniasis: From Innate and Adaptive Immunity to Vaccine Development

Leishmaniasis: From Innate and Adaptive Immunity to Vaccine Development

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ORIGINAL RESEARCH

Published on 23 Apr 2018

Antigenicity of Leishmania-Activated C-Kinase Antigen (LACK) in Human Peripheral Blood Mononuclear Cells, and Protective Effect of Prime-Boost Vaccination With pCI-neo-LACK Plus Attenuated LACK-Expressing Vaccinia Viruses in Hamsters

Laura Fernández
Eugenia Carrillo
Lucas Sánchez-Sampedro
Carmen Sánchez
Ana Victoria Ibarra-Meneses
Mͣ Angeles Jimenez
Valter dos Anjos Almeida
Mariano Esteban
Javier Moreno

doi 10.3389/fimmu.2018.00843

3,024 views
12 citations

ORIGINAL RESEARCH

Published on 15 Mar 2018

New Vaccine Formulations Containing a Modified Version of the Amastigote 2 Antigen and the Non-Virulent Trypanosoma cruzi CL-14 Strain Are Highly Antigenic and Protective against Leishmania infantum Challenge

Ana Paula M. M. Almeida
Leopoldo F. M. Machado
Daniel Doro
Frederico C. Nascimento
Leonardo Damasceno
Ricardo Tostes Gazzinelli
Ana Paula Fernandes
Caroline Junqueira

doi 10.3389/fimmu.2018.00465

3,596 views
15 citations

ORIGINAL RESEARCH

Published on 26 Feb 2018

Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development

Nicole Zimara
Menberework Chanyalew
Abraham Aseffa
Ger van Zandbergen
Bernd Lepenies
Maximilian Schmid
Richard Weiss
Anne Rascle
Anja Kathrin Wege
3 more
Uwe Ritter

doi 10.3389/fimmu.2018.00263

5,700 views
13 citations

REVIEW

Published on 22 Feb 2018

Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Valentin Schatz
Patrick Neubert
Franz Rieger
Jonathan Jantsch

doi 10.3389/fimmu.2018.00216

3,618 views
17 citations

ORIGINAL RESEARCH

Published on 05 Feb 2018

Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control of Leishmania major, but Not for Spontaneous Cure of Subcutaneous Primary or Secondary L. major Infection

Ulrike Schleicher
Jan Liese
Nicole Justies
Thomas Mischke
Simone Haeberlein
Heidi Sebald
Ulrich Kalinke
Siegfried Weiss
Christian Bogdan

doi 10.3389/fimmu.2018.00079

3,962 views
12 citations

ORIGINAL RESEARCH

Published on 24 Jan 2018

Monocyte-Derived Signals Activate Human Natural Killer Cells in Response to Leishmania Parasites

Helena Messlinger
Heidi Sebald
Lukas Heger
Diana Dudziak
Christian Bogdan
Ulrike Schleicher

doi 10.3389/fimmu.2018.00024

17,106 views
19 citations

ORIGINAL RESEARCH

Published on 19 Jan 2018

Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major

Shanshan Hu
Cameron Marshall
Jocelyn Darby
Wei Wei
Alan Bruce Lyons
Heinrich Körner

doi 10.3389/fimmu.2018.00001

5,696 views
201 citations

REVIEW

Published on 22 Dec 2017

Function of Macrophage and Parasite Phosphatases in Leishmaniasis

Didier Soulat
Christian Bogdan

doi 10.3389/fimmu.2017.01838

9,640 views
52 citations

ORIGINAL RESEARCH

Published on 22 Dec 2017

Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner

Christodoulos Filippis
Katharina Arens
Gaetan Aime Noubissi Nzeteu
Gabriele Reichmann
Zoe Waibler
Peter Crauwels
Ger van Zandbergen

doi 10.3389/fimmu.2017.01880

6,185 views
14 citations

REVIEW

Published on 10 Nov 2017

Interleukin-4 Receptor Alpha: From Innate to Adaptive Immunity in Murine Models of Cutaneous Leishmaniasis

Ramona Hurdayal
Frank Brombacher

doi 10.3389/fimmu.2017.01354

11,853 views
32 citations

REVIEW

Published on 08 Nov 2017

Immune Checkpoint Targets for Host-Directed Therapy to Prevent and Treat Leishmaniasis

Rajiv Kumar
Shashi Bhushan Chauhan
Susanna S. Ng
Shyam Sundar
Christian R. Engwerda

doi 10.3389/fimmu.2017.01492

5,387 views
38 citations

REVIEW

Published on 30 Oct 2017

The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis

Suênia da C. Gonçalves-de-Albuquerque
Rômulo Pessoa-e-Silva
Lays A. M. Trajano-Silva
Tayná Correia de Goes
Rayana C. S. de Morais
Cíntia N. da C. Oliveira
Virgínia M. B. de Lorena
Milena de Paiva-Cavalcanti

doi 10.3389/fimmu.2017.01437

9,653 views
107 citations

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Frontiers in Immunology

Microbial Immunology
Vaccines and Molecular Therapeutics

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Articles

Antigenicity of Leishmania-Activated C-Kinase Antigen (LACK) in Human Peripheral Blood Mononuclear Cells, and Protective Effect of Prime-Boost Vaccination With pCI-neo-LACK Plus Attenuated LACK-Expressing Vaccinia Viruses in Hamsters

New Vaccine Formulations Containing a Modified Version of the Amastigote 2 Antigen and the Non-Virulent Trypanosoma cruzi CL-14 Strain Are Highly Antigenic and Protective against Leishmania infantum Challenge

Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development

Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control of Leishmania major, but Not for Spontaneous Cure of Subcutaneous Primary or Secondary L. major Infection

Monocyte-Derived Signals Activate Human Natural Killer Cells in Response to Leishmania Parasites

Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major

Function of Macrophage and Parasite Phosphatases in Leishmaniasis

Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner

Interleukin-4 Receptor Alpha: From Innate to Adaptive Immunity in Murine Models of Cutaneous Leishmaniasis

Immune Checkpoint Targets for Host-Directed Therapy to Prevent and Treat Leishmaniasis

The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis

Frontiers in Immunology

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