Leishmaniasis: From Innate and Adaptive Immunity to Vaccine Development

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Articles

ORIGINAL RESEARCH

Published on 23 Apr 2018

Antigenicity of Leishmania-Activated C-Kinase Antigen (LACK) in Human Peripheral Blood Mononuclear Cells, and Protective Effect of Prime-Boost Vaccination With pCI-neo-LACK Plus Attenuated LACK-Expressing Vaccinia Viruses in Hamsters

Laura Fernández
Eugenia Carrillo
Lucas Sánchez-Sampedro
Carmen Sánchez
Ana Victoria Ibarra-Meneses
Mͣ Angeles Jimenez
Valter dos Anjos Almeida
Mariano Esteban
Javier Moreno

doi 10.3389/fimmu.2018.00843

3,073 views
13 citations

ORIGINAL RESEARCH

Published on 15 Mar 2018

New Vaccine Formulations Containing a Modified Version of the Amastigote 2 Antigen and the Non-Virulent Trypanosoma cruzi CL-14 Strain Are Highly Antigenic and Protective against Leishmania infantum Challenge

Ana Paula M. M. Almeida
Leopoldo F. M. Machado
Daniel Doro
Frederico C. Nascimento
Leonardo Damasceno
Ricardo Tostes Gazzinelli
Ana Paula Fernandes
Caroline Junqueira

doi 10.3389/fimmu.2018.00465

3,638 views
15 citations

ORIGINAL RESEARCH

Published on 26 Feb 2018

Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development

Nicole Zimara
Menberework Chanyalew
Abraham Aseffa
Ger van Zandbergen
Bernd Lepenies
Maximilian Schmid
Richard Weiss
Anne Rascle
Anja Kathrin Wege
3 more
Uwe Ritter

doi 10.3389/fimmu.2018.00263

5,758 views
13 citations

REVIEW

Published on 22 Feb 2018

Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Valentin Schatz
Patrick Neubert
Franz Rieger
Jonathan Jantsch

doi 10.3389/fimmu.2018.00216

3,764 views
18 citations

ORIGINAL RESEARCH

Published on 05 Feb 2018

Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control of Leishmania major, but Not for Spontaneous Cure of Subcutaneous Primary or Secondary L. major Infection

Ulrike Schleicher
Jan Liese
Nicole Justies
Thomas Mischke
Simone Haeberlein
Heidi Sebald
Ulrich Kalinke
Siegfried Weiss
Christian Bogdan

doi 10.3389/fimmu.2018.00079

4,016 views
14 citations

ORIGINAL RESEARCH

Published on 24 Jan 2018

Monocyte-Derived Signals Activate Human Natural Killer Cells in Response to Leishmania Parasites

Helena Messlinger
Heidi Sebald
Lukas Heger
Diana Dudziak
Christian Bogdan
Ulrike Schleicher

doi 10.3389/fimmu.2018.00024

19,129 views
20 citations

ORIGINAL RESEARCH

Published on 19 Jan 2018

Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major

Shanshan Hu
Cameron Marshall
Jocelyn Darby
Wei Wei
Alan Bruce Lyons
Heinrich Körner

doi 10.3389/fimmu.2018.00001

5,786 views
205 citations

REVIEW

Published on 22 Dec 2017

Function of Macrophage and Parasite Phosphatases in Leishmaniasis

Didier Soulat
Christian Bogdan

doi 10.3389/fimmu.2017.01838

9,725 views
55 citations

ORIGINAL RESEARCH

Published on 22 Dec 2017

Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner

Christodoulos Filippis
Katharina Arens
Gaetan Aime Noubissi Nzeteu
Gabriele Reichmann
Zoe Waibler
Peter Crauwels
Ger van Zandbergen

doi 10.3389/fimmu.2017.01880

6,269 views
16 citations

REVIEW

Published on 10 Nov 2017

Interleukin-4 Receptor Alpha: From Innate to Adaptive Immunity in Murine Models of Cutaneous Leishmaniasis

Ramona Hurdayal
Frank Brombacher

doi 10.3389/fimmu.2017.01354

12,030 views
33 citations

REVIEW

Published on 08 Nov 2017

Immune Checkpoint Targets for Host-Directed Therapy to Prevent and Treat Leishmaniasis

Rajiv Kumar
Shashi Bhushan Chauhan
Susanna S. Ng
Shyam Sundar
Christian R. Engwerda

doi 10.3389/fimmu.2017.01492

5,441 views
41 citations

REVIEW

Published on 30 Oct 2017

The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis

Suênia da C. Gonçalves-de-Albuquerque
Rômulo Pessoa-e-Silva
Lays A. M. Trajano-Silva
Tayná Correia de Goes
Rayana C. S. de Morais
Cíntia N. da C. Oliveira
Virgínia M. B. de Lorena
Milena de Paiva-Cavalcanti

doi 10.3389/fimmu.2017.01437

9,747 views
109 citations

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Frontiers in Immunology

Microbial Immunology
Vaccines and Molecular Therapeutics

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Articles

Antigenicity of Leishmania-Activated C-Kinase Antigen (LACK) in Human Peripheral Blood Mononuclear Cells, and Protective Effect of Prime-Boost Vaccination With pCI-neo-LACK Plus Attenuated LACK-Expressing Vaccinia Viruses in Hamsters

New Vaccine Formulations Containing a Modified Version of the Amastigote 2 Antigen and the Non-Virulent Trypanosoma cruzi CL-14 Strain Are Highly Antigenic and Protective against Leishmania infantum Challenge

Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development

Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control of Leishmania major, but Not for Spontaneous Cure of Subcutaneous Primary or Secondary L. major Infection

Monocyte-Derived Signals Activate Human Natural Killer Cells in Response to Leishmania Parasites

Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major

Function of Macrophage and Parasite Phosphatases in Leishmaniasis

Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner

Interleukin-4 Receptor Alpha: From Innate to Adaptive Immunity in Murine Models of Cutaneous Leishmaniasis

Immune Checkpoint Targets for Host-Directed Therapy to Prevent and Treat Leishmaniasis

The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis

Frontiers in Immunology

Microbial Immunology

Vaccines and Molecular Therapeutics