About this Research Topic
Active electric properties of neurons and silent electric features of glia define the respective functions of excitable and non-excitable cells. The interaction between neurons and glia occurs in an omnidirectional cascade. Upon injury or exposure to brain insults, the morphological and functional features get disrupted, resulting in an alteration of the homeostatic signaling cascade. Little is understood about the role and functions of different ion channels, cytokines, receptors, and their effective targets.
In particular, the glial physiology and pathology during the different brain states help to understand disease mechanisms in detail for therapeutic interventions. The interaction of glia and neurons along with the blood-brain barrier during reactive gliosis or neurodegeneration can pave the way for the dissemination of how the small molecules (examples, exosomes, vesicles, cytokines, hormones, or any antigen) reach the bloodstream and trigger the local resident cells. Excessive entry or block of specific ion channels results in genetic variation, post-secondary modifications, and protein expression level changes that have direct relevance to neuropsychiatric and neurodegenerative disorders. Specifically, astrocyte-linked physiology and pathophysiology will be the main highlights of this release, accommodating brain inflammation, and small molecule-related mechanisms that interfere with omnidirectional signaling.
All these are feasible at the expense of the bioenergetics in the normal states, and they get seriously hampered in the disease state. Understanding the physiological and pathological processes focusing on the neurons and astrocytes in the discrete brain regions and the signaling is essential to understanding how the brain works in health and disease. The author (s) who are interested in these areas of research are highly welcome to submit their experimental and theoretical perspectives to Frontiers in Cellular Neuroscience.
This Research Topic welcomes Original Research articles, Reviews, Mini Review, and Perspectives, focused, but not limited to the following subtopics:
1. Occupational Metals associated hazards with neurological disorders
a) Magnesium in channels of the cellular system
b) Manganese in Parkinson’s disease
c) Aluminium, Iron in Alzheimer’s disease, and so on.
d) Deficiency and excess of essential metals
e) Biomarkers of glia in neurological disorders
2. Toxins or blockers as a tool to study ion changes with a focus on the non-neuronal cells
a) Na ions (Intracellular and extracellular)
b) K ions (intracellular and extracellular)
c) Ca ions (Intracellular and extracellular)
d) Water channels
3. Reactive astrocytes
a) Inflammation
b) Astrocyte phenotypic transformation during astrogliosis
c) Diseases of astrocytic origin
d) Disruption of neuron-glia communication and emergence of psychiatric disorders
e) Bio-energetics in the brain circuit
In particular, the glial physiology and pathology during the different brain states help to understand disease mechanisms in detail for therapeutic interventions. The interaction of glia and neurons along with the blood-brain barrier during reactive gliosis or neurodegeneration can pave the way for the dissemination of how the small molecules (examples, exosomes, vesicles, cytokines, hormones, or any antigen) reach the bloodstream and trigger the local resident cells. Excessive entry or block of specific ion channels results in genetic variation, post-secondary modifications, and protein expression level changes that have direct relevance to neuropsychiatric and neurodegenerative disorders. Specifically, astrocyte-linked physiology and pathophysiology will be the main highlights of this release, accommodating brain inflammation, and small molecule-related mechanisms that interfere with omnidirectional signaling.
All these are feasible at the expense of the bioenergetics in the normal states, and they get seriously hampered in the disease state. Understanding the physiological and pathological processes focusing on the neurons and astrocytes in the discrete brain regions and the signaling is essential to understanding how the brain works in health and disease. The author (s) who are interested in these areas of research are highly welcome to submit their experimental and theoretical perspectives to Frontiers in Cellular Neuroscience.
This Research Topic welcomes Original Research articles, Reviews, Mini Review, and Perspectives, focused, but not limited to the following subtopics:
1. Occupational Metals associated hazards with neurological disorders
a) Magnesium in channels of the cellular system
b) Manganese in Parkinson’s disease
c) Aluminium, Iron in Alzheimer’s disease, and so on.
d) Deficiency and excess of essential metals
e) Biomarkers of glia in neurological disorders
2. Toxins or blockers as a tool to study ion changes with a focus on the non-neuronal cells
a) Na ions (Intracellular and extracellular)
b) K ions (intracellular and extracellular)
c) Ca ions (Intracellular and extracellular)
d) Water channels
3. Reactive astrocytes
a) Inflammation
b) Astrocyte phenotypic transformation during astrogliosis
c) Diseases of astrocytic origin
d) Disruption of neuron-glia communication and emergence of psychiatric disorders
e) Bio-energetics in the brain circuit
Keywords: ion channels, psychiatric disorders, Ca-channels, K-channels, ocupational metals, neurological disorders, glia, astrocytes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
