About this Research Topic
Tractometry methods extract valuable information from white matter tracts reconstructed from Diffusion MRI using tractography methods. By combining tractography with advanced computational techniques, tractometry allows for measuring and characterizing various properties along the length of white matter tracts, offering unique insights into brain connectivity. Tractometry enables the evaluation of microstructural properties within white matter tracts. Metrics such as fractional anisotropy can be computed along the length of the tracts, providing information about tissue integrity, myelination, and axonal density. This helps assess the microstructural alterations associated with neurodegenerative diseases, brain injury, or developmental disorders. Tractometry facilitates the analysis of group comparisons, helping to identify statistically significant differences in tract properties between populations or clinical cohorts. Tractometry contributes to understanding brain connectivity and its role in health, disease, and neurological function.
The goal is to apply existing novel tractometry methods to analyze quantitatively and characterize white matter tracts in the brain to gain insights into their microstructural properties, connectivity patterns, and functional relevance. With tractometry, more profound insights can be gained into the tract-specific alterations, biomarkers, disease mechanisms, and progression associated with neurodegenerative diseases and other brain conditions, such as Alzheimer's, Parkinson's', Multiple sclerosis, Bipolar disorder, Schizophrenia, and ADHD.
This Research Topic aims to explore the diverse methods and applications of diffusion MRI tractometry in the field of neuroscience. It welcomes contributions that make use of tractometry techniques, demonstrate their utility in various research domains, and shed light on their applications in studying brain connectivity and neurological conditions.
Themes of particular interest:
Tractometry applications in neurological disorders (e.g., Alzheimer, Parkinsons), psychiatric disorders (e.g., schizophrenia, depression), developmental disorders (e.g., autism spectrum disorders, ADHD), and studying stroke, traumatic brain injury, and other acquired brain injuries.
Investigating the relationship between white matter tracts and behavioral outcomes and cognitive function.
Longitudinal assessment of disease progression and therapeutic
interventions or age-related changes in white matter connectivity.
The goal is to apply existing novel tractometry methods to analyze quantitatively and characterize white matter tracts in the brain to gain insights into their microstructural properties, connectivity patterns, and functional relevance. With tractometry, more profound insights can be gained into the tract-specific alterations, biomarkers, disease mechanisms, and progression associated with neurodegenerative diseases and other brain conditions, such as Alzheimer's, Parkinson's', Multiple sclerosis, Bipolar disorder, Schizophrenia, and ADHD.
This Research Topic aims to explore the diverse methods and applications of diffusion MRI tractometry in the field of neuroscience. It welcomes contributions that make use of tractometry techniques, demonstrate their utility in various research domains, and shed light on their applications in studying brain connectivity and neurological conditions.
Themes of particular interest:
Tractometry applications in neurological disorders (e.g., Alzheimer, Parkinsons), psychiatric disorders (e.g., schizophrenia, depression), developmental disorders (e.g., autism spectrum disorders, ADHD), and studying stroke, traumatic brain injury, and other acquired brain injuries.
Investigating the relationship between white matter tracts and behavioral outcomes and cognitive function.
Longitudinal assessment of disease progression and therapeutic
interventions or age-related changes in white matter connectivity.
Keywords: diffusion, diffusion mri, neuroscience, neurological disorders, mri, tractography, tractometry
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
