About this Research Topic
In recent years, there has been rapid progress in the clinical application of immune checkpoint inhibitors against cancers of various organs, and there has been a high level of interest in the study of cancer immunity. On the other hand, it has long been known that the fetus is spared from attack by maternal immune mechanisms during pregnancy. In humans, during the process of placentation, embryo-derived extravillous trophoblast cells invade the endometrium and blood vessels to reconstruct maternal tissues. However, the details of the mechanism by which these cells acquire immune tolerance immediately after embryo implantation have not yet been elucidated.
It is speculated that a common mechanism exists between embryos and cancer cells in the acquisition of immune tolerance. Analysis of the mechanisms of cancer immunity from this perspective may lead to the development of novel cancer immunotherapy, and may also provide new therapeutic guidelines for the effects of pregnancy on cancer immunity, which have not been fully understood. This Research Topic aims to bring together studies that elucidate new aspects of cancer immune mechanisms focusing on immune evasion mechanisms in the embryo/fetus and cancer progression during pregnancy. Our academic goal is to develop new research areas by integrating reproductive and perinatal medicine and oncology.
We welcome Original Research, Clinical Trials, Hypotheses & Theories, Mini Reviews and Reviews of ambitious research aimed at elucidating common mechanisms between embryos and cancer cells in the acquisition of immune tolerance, changes in cancer immune function during pregnancy and their mechanisms, epidemiological studies, and developing preventive, diagnostic, and therapeutic methods based on these mechanisms. Kindly note that Case Reports will not be considered in this Research Topic.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
It is speculated that a common mechanism exists between embryos and cancer cells in the acquisition of immune tolerance. Analysis of the mechanisms of cancer immunity from this perspective may lead to the development of novel cancer immunotherapy, and may also provide new therapeutic guidelines for the effects of pregnancy on cancer immunity, which have not been fully understood. This Research Topic aims to bring together studies that elucidate new aspects of cancer immune mechanisms focusing on immune evasion mechanisms in the embryo/fetus and cancer progression during pregnancy. Our academic goal is to develop new research areas by integrating reproductive and perinatal medicine and oncology.
We welcome Original Research, Clinical Trials, Hypotheses & Theories, Mini Reviews and Reviews of ambitious research aimed at elucidating common mechanisms between embryos and cancer cells in the acquisition of immune tolerance, changes in cancer immune function during pregnancy and their mechanisms, epidemiological studies, and developing preventive, diagnostic, and therapeutic methods based on these mechanisms. Kindly note that Case Reports will not be considered in this Research Topic.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: cancer immunology, cytokines, embryo, immune tolerance, pregnancy, T cells
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
