About this Research Topic
Pulmonary vascular disease (PVD) is a group of disorders that affect the blood vessels in the lungs, including pulmonary hypertension, pulmonary embolism, and pulmonary fibrosis, among others. These diseases are associated with high morbidity and mortality rates and pose significant challenges to clinical management. Despite significant progress in understanding the pathogenesis of PVD, effective treatments for these diseases remain limited. Recent research has suggested that epigenetic modifications, which regulate gene expression without altering the DNA sequence, may play a crucial role in the development and progression of PVD. For example, epigenetic modifications such as DNA methylation and histone modifications can affect gene expression and have been shown to be dysregulated in PVD. Additionally, microRNAs, a type of small non-coding RNA that can regulate gene expression, have also been implicated in PVD pathogenesis.
While significant progress has been made in understanding PVD, effective treatments for these diseases remain limited. It is therefore crucial to explore new avenues for therapeutic intervention. Epigenetic modifications have emerged as a promising area of research, as they can regulate gene expression and have been shown to be dysregulated in PVD. By identifying specific epigenetic modifications that are involved in PVD pathogenesis and understanding how they impact the underlying molecular mechanisms, researchers can identify potential new targets for therapeutic intervention.
This Research Topic aims to explore research that investigates the role of epigenetic modifications in the pathogenesis of pulmonary vascular disease (PVD). Specific themes to address could include the identification and characterization of specific epigenetic modifications that are involved in the development and progression of PVD, the impact of these modifications on the underlying molecular mechanisms, and the potential for targeting these modifications as a therapeutic strategy.
Researchers should also explore the potential for using epigenetic markers as diagnostic tools for PVD and investigate the clinical relevance of these markers. Additional themes could include the development and validation of animal models of PVD to study epigenetic modifications in vivo, and the use of omics technologies, such as transcriptomics, epigenomics, and proteomics, to gain a deeper understanding of PVD pathogenesis at a molecular level.
The scope of this Research Topic is broad, and authors are encouraged to submit original research articles, reviews, mini-reviews, perspectives, general commentary, as well as opinions, and methods relevant to this topic.
While significant progress has been made in understanding PVD, effective treatments for these diseases remain limited. It is therefore crucial to explore new avenues for therapeutic intervention. Epigenetic modifications have emerged as a promising area of research, as they can regulate gene expression and have been shown to be dysregulated in PVD. By identifying specific epigenetic modifications that are involved in PVD pathogenesis and understanding how they impact the underlying molecular mechanisms, researchers can identify potential new targets for therapeutic intervention.
This Research Topic aims to explore research that investigates the role of epigenetic modifications in the pathogenesis of pulmonary vascular disease (PVD). Specific themes to address could include the identification and characterization of specific epigenetic modifications that are involved in the development and progression of PVD, the impact of these modifications on the underlying molecular mechanisms, and the potential for targeting these modifications as a therapeutic strategy.
Researchers should also explore the potential for using epigenetic markers as diagnostic tools for PVD and investigate the clinical relevance of these markers. Additional themes could include the development and validation of animal models of PVD to study epigenetic modifications in vivo, and the use of omics technologies, such as transcriptomics, epigenomics, and proteomics, to gain a deeper understanding of PVD pathogenesis at a molecular level.
The scope of this Research Topic is broad, and authors are encouraged to submit original research articles, reviews, mini-reviews, perspectives, general commentary, as well as opinions, and methods relevant to this topic.
Keywords: epigenetic, pulmonary vascular diseases, DNA methylation, microRNA, histone modification, long-noncoding RNA
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