About this Research Topic
Neuroinflammation is defined as an inflammatory response within the brain or spinal cord characterized by the activation of brain glial cells, principally microglia and astrocytes, that release several soluble factors and proinflammatory cytokines leading to neurotoxicity and neuronal dysfunction.
It is well established that neuroinflammation is involved in the onset or progression of various neurological and neurodegenerative diseases including Multiple Sclerosis, stroke, Parkinson’s disease, Alzheimer’s disease and Amyotrophic Lateral Sclerosis. In addition, growing evidence indicates that chronic low-grade neuroinflammation is also involved in the pathogenesis of psychiatric diseases such as autism spectrum disorders, depression and schizophrenia. However, it is still not clear whether the neuroinflammatory processes are a cause or a consequence of these complex diseases.
Further understanding of the intracellular molecular mechanism that are at the origin of the association between inflammation and neurodegenerative and psychiatric disorders may allow the identification of new biomarkers and provide novel ways to develop new treatment strategies. We invite authors to submit Original Research and Review articles related to any of these aspects.
It is well established that neuroinflammation is involved in the onset or progression of various neurological and neurodegenerative diseases including Multiple Sclerosis, stroke, Parkinson’s disease, Alzheimer’s disease and Amyotrophic Lateral Sclerosis. In addition, growing evidence indicates that chronic low-grade neuroinflammation is also involved in the pathogenesis of psychiatric diseases such as autism spectrum disorders, depression and schizophrenia. However, it is still not clear whether the neuroinflammatory processes are a cause or a consequence of these complex diseases.
Further understanding of the intracellular molecular mechanism that are at the origin of the association between inflammation and neurodegenerative and psychiatric disorders may allow the identification of new biomarkers and provide novel ways to develop new treatment strategies. We invite authors to submit Original Research and Review articles related to any of these aspects.
Keywords: neuroinflammation, neurodegeneration, intracellular, molecular mechanisms, psychiatric disorders, neuropsychiatric, microglia, astrocytes, cytokines
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