About this Research Topic
Although a design of new chemotherapy agents is growing quickly, effective chemotherapy agents have not been discovered against the advanced stage of cancer, particularly invasion and metastasis. With this Research Topic, we aim to shed light on lines of investigation that show great promise, in particular, a focus on novel approaches that have recently been uncovered in the field, ranging from fundamental genetics to genomic engineering, to omics techniques, to artificial intelligence & machine learning to reveal the molecular basis of drug resistance in different cancers so as to guide clinicians design and develop therapeutic strategies to enhance therapeutic drug sensitivity and overcome resistance. Articles outlining innovative strategies and openly discussing the shortcomings of current methodologies with appropriate solutions are required.
Our proposed edition would have a collection of research & review articles with a focus on analyzing different sorts of patients’ disease multi-omics data, integrating & developing predictive models, and deriving testable hypotheses for enlightening the scientific community about the molecular basis of drug resistance in different cancers.
We would be interested in manuscripts falling into one of the below-mentioned categories:
• Identification of new genetic, epigenetic, and other molecular factors responsible for drug resistance
• Role of cancer stem cells in drug resistance
• Role of non-coding RNAs in drug resistance
• Applications of different omics technologies in unraveling the molecular basis of therapeutic drug resistance
• Applications of computational biology, computer-aided drug design, structural biology, and bioinformatics approaches in drug design, development, and repurposing
• Pros and cons of drug repositioning in cancer therapy
• Opinion/perspective on cancer microenvironment challenges and possible solutions
Keywords: cancer, drug resistance, genetic, epigenetic, non-coding RNAs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.