About this Research Topic
Gastrointestinal cancer is one of the most common and aggressive malignant tumors of the digestive system in the world, with its morbidity and mortality ranking at the forefront of malignant tumors. Currently, clinical immunotherapy mainly includes immune checkpoint inhibitors (ICI), adoptive immunotherapy (AIT), and combined immunotherapy for cancer (CIC), which can reactivate the host immune system to fight against tumor cells. However, it ignores the intercellular metabolic crosstalk existing in the tumor microenvironment (TME) may result in the polarization of immune cells, thus displaying tumor-promoting properties, supporting tumor immune escape, and leading to tumor growth and invasion.
Numerous studies have shown that TME is conducive to the growth and expansion of cancer cells, and the dynamic change of TME heterogeneity is closely related to immune cells. Constant interactions between cancer and stromal cells lead to metabolic competition and symbiosis, with oncogene-driven metabolic reprogramming of cancer cells shaping the metabolism of neighboring cells and vice versa. Such metabolic crosstalk may affect cancer progression and even lead to immune escape. Therefore, enhancing the understanding of how metabolism in the TME in gastrointestinal cancer modulates cancer development and evasion of tumor-suppressive mechanisms may provide ideas for novel anticancer therapies targeting metabolic targets.
This Research Topic aims to assemble a series of articles that address the current understanding of intercellular metabolic crosstalk and immune escape in the gastrointestinal tumor microenvironment. Subtopics may include, but are not limited to:
1. Reviews of high-quality literature on intercellular metabolic crosstalk and immune escape in the gastrointestinal tumor microenvironment;
2. Mechanism of intercellular metabolic crosstalk in the gastrointestinal tumor microenvironment and the subsequent effect on the host immune system;
3. Potential targets and therapeutic strategies for intercellular metabolic crosstalk in the gastrointestinal tumor microenvironment to affect tumor immune escape.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
Numerous studies have shown that TME is conducive to the growth and expansion of cancer cells, and the dynamic change of TME heterogeneity is closely related to immune cells. Constant interactions between cancer and stromal cells lead to metabolic competition and symbiosis, with oncogene-driven metabolic reprogramming of cancer cells shaping the metabolism of neighboring cells and vice versa. Such metabolic crosstalk may affect cancer progression and even lead to immune escape. Therefore, enhancing the understanding of how metabolism in the TME in gastrointestinal cancer modulates cancer development and evasion of tumor-suppressive mechanisms may provide ideas for novel anticancer therapies targeting metabolic targets.
This Research Topic aims to assemble a series of articles that address the current understanding of intercellular metabolic crosstalk and immune escape in the gastrointestinal tumor microenvironment. Subtopics may include, but are not limited to:
1. Reviews of high-quality literature on intercellular metabolic crosstalk and immune escape in the gastrointestinal tumor microenvironment;
2. Mechanism of intercellular metabolic crosstalk in the gastrointestinal tumor microenvironment and the subsequent effect on the host immune system;
3. Potential targets and therapeutic strategies for intercellular metabolic crosstalk in the gastrointestinal tumor microenvironment to affect tumor immune escape.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
Keywords: Metabolic Crosstalk, Gastrointestinal Tumor, Tumor Microenvironment, Immune Escape
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
