About this Research Topic
When blood is transfused from one individual to another, there are potentials for immune responses due to incompatibilities between donor and recipients. The responses are dependent on immune status of the patients and the nature of the blood components, such as red cells, plasma, platelets, granulocytes and lymphocytes, used as single components or in combinations.
To understand the immune responses related to transfusion, it is necessary to recognize the features of basic immunology, followed by knowledge on the specific antigens present on the red cells, leukocytes and platelets – and the antibody responses to stimulation with these antigens. Autoimmune conditions also apply. Transfusion is causing immunomodulation and transfusion reactions related to immune responses in the recipient. In addition, both clinical and feto-maternal transfusions cause immune responses that may affect the fetus, the newborn child and the pregnant woman.
Transfusion medicine and immunology are often regarded as two different fields of medicine, even though immune reactions are essential in transfusion. The intentions of this research topic are to provide up-to-date information that will provide mutual benefit to both specialists in transfusion medicine and immunologists who work in fields unrelated to transfusion. Bringing immunologists and transfusionists together may create collaborations that may benefit future research in basal immunology and clinical transfusion practice.
In this Research Topic, we welcome the submission of Original Research, Reviews, Mini-Reviews, Perspective and Clinical trial articles that include updated information on:
• The Human Immunological Response and How it Works
• Immunogenetics and Blood Group Terminology (Red Blood Cells,Platelets,Granulocytes, Lymphocytes)
• Pheno- and genotyping of transfusion related antigens. Antibody detection.
• Acute immunological transfusion reactions
• Chronic immunological transfusion reactions
• Immunological consequences of leukocyte depletion of blood components
• Transfusion Medicine in Obstetrics and Neonatology
• Immune responses in the severely injured patient and consequences for transfusion
• Immunodeficiencies associated with blood transfusions
• Immunological effects of immunoglobulin therapy
• Autoimmunity in transfusion
• Miscellaneous immunological conditions in Transfusion Medicine.
To understand the immune responses related to transfusion, it is necessary to recognize the features of basic immunology, followed by knowledge on the specific antigens present on the red cells, leukocytes and platelets – and the antibody responses to stimulation with these antigens. Autoimmune conditions also apply. Transfusion is causing immunomodulation and transfusion reactions related to immune responses in the recipient. In addition, both clinical and feto-maternal transfusions cause immune responses that may affect the fetus, the newborn child and the pregnant woman.
Transfusion medicine and immunology are often regarded as two different fields of medicine, even though immune reactions are essential in transfusion. The intentions of this research topic are to provide up-to-date information that will provide mutual benefit to both specialists in transfusion medicine and immunologists who work in fields unrelated to transfusion. Bringing immunologists and transfusionists together may create collaborations that may benefit future research in basal immunology and clinical transfusion practice.
In this Research Topic, we welcome the submission of Original Research, Reviews, Mini-Reviews, Perspective and Clinical trial articles that include updated information on:
• The Human Immunological Response and How it Works
• Immunogenetics and Blood Group Terminology (Red Blood Cells,Platelets,Granulocytes, Lymphocytes)
• Pheno- and genotyping of transfusion related antigens. Antibody detection.
• Acute immunological transfusion reactions
• Chronic immunological transfusion reactions
• Immunological consequences of leukocyte depletion of blood components
• Transfusion Medicine in Obstetrics and Neonatology
• Immune responses in the severely injured patient and consequences for transfusion
• Immunodeficiencies associated with blood transfusions
• Immunological effects of immunoglobulin therapy
• Autoimmunity in transfusion
• Miscellaneous immunological conditions in Transfusion Medicine.
Keywords: Blood Transfusion; Transfusion Medicine, Immunology, Red Blood Cells, Platelets, Leucocytes, Granulocytes, Lymphocytes, Neonatal Alloimmune Throbocytopenia, Hemolytic Disease of Fetus and Newborn, Graft-versus-host disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
