About this Research Topic
Furthermore, there are also numerous splice variants due to rampant post-translational modifications, controlled by unclear regulatory schemes, that play important roles to healthy muscle tension production and development. These features make titin an incredibly interesting system to study, and a focus is needed to identify the mechanisms behind titin's various regulatory roles.
While many skeletal and cardiomyopathies can be associated to a dysfunction or modification in titin, it is not always clear what mechanism connects the titin dysfunction to the cellular disease state.
The goal of this Research Topic is to compile research that specifically tries to define these mechanisms. The aim of this special edition is to develop a collection of articles that focus on titin’s function in both cardiac and skeletal muscle. These articles will focus on the various binding interactions that involve titin, disease states involving titin and the role of titin in both passive and active muscle. This collection will include new research findings as well as a series of review articles focused on specific aspects of titin function.
Topic Editor Dr. Anthony Hessel is a co-founder and CEO of Accelerated Muscle Biotechnologies, LLC (AMB). Topic Editor Dr. Charles Chung has patent disclosures related to diastolic function (patents 8,355,548 & 8,273,029) and cardiac structure (fibrosis; disclosure submitted). The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Titin, Connectin, Sarcomere, Binding Interactions, Muscle Adaptation, Cell Signaling, Cardiomyopathies, History-dependent Properties
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.