Traditional Clinical Symptoms and Signs: How Can They Be Used to Investigate Medications in the Context of Pharmacology?

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EDITORIAL

Accepted on 11 Mar 2025

Symptom-Driven Drug Development: Bridging Traditional Chinese Medicine and Western Pharmacology Editorial: Traditional Clinical Symptoms and Signs: How Can They Be Used to Investigate Medications in the Context of Pharmacology?

Kuo Gao
Michael Heinrich
Hui Hui Zhao
Xuezhong Zhou
Shao Li

doi 10.3389/fphar.2025.1588000

ORIGINAL RESEARCH

Published on 25 Oct 2024

Machine learning model for predicting the cold–heat pattern in Kampo medicine: a multicenter prospective observational study

Ayako Maeda-Minami
Tetsuhiro Yoshino
Kotoe Katayama
Yuko Horiba
Hiroaki Hikiami
Yutaka Shimada
Takao Namiki
Eiichi Tahara
Kiyoshi Minamizawa
8 more
Kenji Watanabe

doi 10.3389/fphar.2024.1412593

505 views

ORIGINAL RESEARCH

Published on 09 Oct 2024

Zhachong Shisanwei pill drug-containing serum protects H2O2-Induced PC12 cells injury by suppressing apoptosis, oxidative stress via regulating the MAPK signaling pathway

Hanqiong Hu
Yifan Sun
Zhen Yang
Limuge Che
Mingyang Cai
Xiaoxuan Li
Xianju Huang
Hurile Bagen
Wulan Qiqige
2 more
Haiying Tong

doi 10.3389/fphar.2024.1445597

806 views

ORIGINAL RESEARCH

Published on 27 Sep 2024

Traditional clinical symptoms and signs: Kampo pattern diagnosis in modern gastrointestinal disease

Paul Zedler
Judith Büntzel
Kenny Kuchta
Denichiro Yamaoka
Nanoha Sato
Kenji Watanabe
Silke Cameron

doi 10.3389/fphar.2024.1426491

683 views

ORIGINAL RESEARCH

Published on 16 Sep 2024

Bushen Huoxue formula attenuates lipid accumulation evoking excessive autophagy in premature ovarian insufficiency rats and palmitic acid-challenged KGN cells by modulating lipid metabolism

Tian Li
Yao Wei
Beibie Jiao
Rui Hao
Beibei Zhou
Xinlan Bian
Peijuan Wang
Yahong Zhou
Xia Sun
Jian Zhang

doi 10.3389/fphar.2024.1425844

1,212 views

ORIGINAL RESEARCH

Published on 07 Aug 2024

Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records

Yu-man Wang
Jian-hui Sun
Run-xue Sun
Xiao-yu Liu
Jing-fan Li
Run-ze Li
Yan-ru Du
Xue-zhong Zhou

doi 10.3389/fphar.2024.1444733

1,465 views
1 citation

ORIGINAL RESEARCH

Published on 29 Jul 2024

Integrating transcriptomics and metabolomics to reveal the protective effect and mechanism of Bushen Kangshuai Granules on the elderly people

Jun Hu
Fengmin Yang
Guang Yang
Juhua Pan
Yumeng Tan
Yalin Tang
Yongmei Liu
Hong Zhang
Jie Wang

doi 10.3389/fphar.2024.1361284

986 views

ORIGINAL RESEARCH

Published on 29 Jul 2024

High throughput mRNA sequencing reveals potential therapeutic targets of Si-Ni-San in the pons for a stress-induced depression model

Junling Li
Yan Zhang
Te Li
Binbin Nie
Fang Qi
Qijun Chen
Tianxing Chen
Yuhang Liu
Gaifen Li
Yubo Li

doi 10.3389/fphar.2024.1383624

980 views

ORIGINAL RESEARCH

Published on 20 Jun 2024

Traditional Chinese Medicine JianPiHuaTan formula improving quality of life and survival in patients with colorectal cancer through RAS/RAF downstream signaling pathways

Jian He
Guojun Li
Yu Wu
Tong Zhang
Mingjiang Yao
Mingxuan Zang
Jianhua Zou
Jinjie Song
Liusheng Li
2 more
Linlin Cai

doi 10.3389/fphar.2024.1391399

1,046 views

ORIGINAL RESEARCH

Published on 06 Jun 2024

Molecular mechanism of the treatment of lung adenocarcinoma by Hedyotis Diffusa: an integrative study with real-world clinical data and experimental validation

Sheng Wang
Na Yin
Yingyue Li
Zhaohang Ma
Wei Lin
Lihong Zhang
Yun Cui
Jianan Xia
Liang Geng

doi 10.3389/fphar.2024.1355531

773 views

ORIGINAL RESEARCH

Published on 25 Oct 2023

Investigation of anti-depression effects and potential mechanisms of the ethyl acetate extract of Cynomorium songaricum Rupr. through the integration of in vivo experiments, LC-MS/MS chemical analysis, and a systems biology approach

Xinyu Zhang
Lingling Li
Jianxin Chen
Mengyuan Hu
Yali Zhang
Xuya Zhang
Yi Lu

doi 10.3389/fphar.2023.1239197

2,329 views
5 citations

REVIEW

Published on 16 Aug 2023

Role of traditional Chinese medicine monomers in cerebral ischemia/reperfusion injury:a review of the mechanism

Ting Zheng
Taotao Jiang
Zilong Huang
Hongxiang Ma
Manxia Wang

doi 10.3389/fphar.2023.1220862

2,965 views
19 citations

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Articles

Symptom-Driven Drug Development: Bridging Traditional Chinese Medicine and Western Pharmacology Editorial: Traditional Clinical Symptoms and Signs: How Can They Be Used to Investigate Medications in the Context of Pharmacology?

Machine learning model for predicting the cold–heat pattern in Kampo medicine: a multicenter prospective observational study

Zhachong Shisanwei pill drug-containing serum protects H2O2-Induced PC12 cells injury by suppressing apoptosis, oxidative stress via regulating the MAPK signaling pathway

Traditional clinical symptoms and signs: Kampo pattern diagnosis in modern gastrointestinal disease

Bushen Huoxue formula attenuates lipid accumulation evoking excessive autophagy in premature ovarian insufficiency rats and palmitic acid-challenged KGN cells by modulating lipid metabolism

Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records

Integrating transcriptomics and metabolomics to reveal the protective effect and mechanism of Bushen Kangshuai Granules on the elderly people

High throughput mRNA sequencing reveals potential therapeutic targets of Si-Ni-San in the pons for a stress-induced depression model

Traditional Chinese Medicine JianPiHuaTan formula improving quality of life and survival in patients with colorectal cancer through RAS/RAF downstream signaling pathways

Molecular mechanism of the treatment of lung adenocarcinoma by Hedyotis Diffusa: an integrative study with real-world clinical data and experimental validation

Investigation of anti-depression effects and potential mechanisms of the ethyl acetate extract of Cynomorium songaricum Rupr. through the integration of in vivo experiments, LC-MS/MS chemical analysis, and a systems biology approach

Role of traditional Chinese medicine monomers in cerebral ischemia/reperfusion injury:a review of the mechanism

Frontiers in Pharmacology

Ethnopharmacology