Frontiers | Pathogenic Potassium Channel Variants in Neurological Disorders: From Functional Analysis to Personalized Pharmacological Approaches

Pathogenic Potassium Channel Variants in Neurological Disorders: From Functional Analysis to Personalized Pharmacological Approaches

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ORIGINAL RESEARCH

Published on 24 Jan 2025

Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes

Ilaria Filareto
Ilaria Mosca
Elena Freri
Francesca Ragona
Laura Canafoglia
Roberta Solazzi
Barbara Castellotti
Giuliana Messina
Cinzia Gellera
4 more
Tiziana Granata

doi 10.3389/fncel.2024.1512365

329 views

ORIGINAL RESEARCH

Published on 14 Oct 2024

A novel loss-of-function KCNB1 gene variant in a twin with global developmental delay and seizures

Rían W. Manville
Claire L. Illeck
Cesar Santos
Richard Sidlow
Geoffrey W. Abbott

A novel loss-of-function KCNB1 gene variant in a twin with global developmental delay and seizures

doi 10.3389/fncel.2024.1477989

718 views

ORIGINAL RESEARCH

Published on 02 Oct 2024

A novel KCNC3 gene variant in the voltage-dependent Kv3.3 channel in an atypical form of SCA13 with dominant central vertigo

Felix P. Bernhard
Sven Schütte
Moritz Heidenblut
Moritz Oehme
Susanne Rinné
Niels Decher

A novel KCNC3 gene variant in the voltage-dependent Kv3.3 channel in an atypical form of SCA13 with dominant central vertigo

doi 10.3389/fncel.2024.1441257

763 views

REVIEW

Published on 01 Oct 2024

Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders

Isabel E. Faulkner
Rachael Z. Pajak
Michael K. Harte
Jocelyn D. Glazier
Reinmar Hager

Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders

doi 10.3389/fncel.2024.1449151

1,289 views

ORIGINAL RESEARCH

Published on 08 Aug 2024

Donepezil as a new therapeutic potential in KCNQ2- and KCNQ3-related autism

Andreea Nissenkorn
Lior Bar
Ariel Ben-Bassat
Lynn Rothstein
Hoda Abdelrahim
Riki Sokol
Lidia V. Gabis
Bernard Attali

Donepezil as a new therapeutic potential in KCNQ2- and KCNQ3-related autism

doi 10.3389/fncel.2024.1380442

1,860 views

OPINION

Published on 30 Jul 2024

Potassium channels in animal models of post-traumatic stress disorder: mechanistic and therapeutic implications

Ravi Philip Rajkumar

Potassium channels in animal models of post-traumatic stress disorder: mechanistic and therapeutic implications

doi 10.3389/fncel.2024.1441514

820 views

ORIGINAL RESEARCH

Published on 29 Jul 2024

A novel autism-associated KCNB1 mutation dramatically slows Kv2.1 potassium channel activation, deactivation and inactivation

Rían W. Manville
Samantha D. Block
Claire L. Illeck
Jessica Kottmeier
Richard Sidlow
Geoffrey W. Abbott

A novel autism-associated KCNB1 mutation dramatically slows Kv2.1 potassium channel activation, deactivation and inactivation

doi 10.3389/fncel.2024.1438101

1,409 views
1 citation

CASE REPORT

Published on 04 Apr 2024

Case report: Marked electroclinical improvement by fluoxetine treatment in a patient with KCNT1-related drug-resistant focal epilepsy

Ilaria Mosca
Elena Freri
Paolo Ambrosino
Giorgio Belperio
Tiziana Granata
Laura Canafoglia
Francesca Ragona
Roberta Solazzi
Ilaria Filareto
5 more
Maurizio Taglialatela

Case report: Marked electroclinical improvement by fluoxetine treatment in a patient with KCNT1-related drug-resistant focal epilepsy

doi 10.3389/fncel.2024.1367838

1,478 views
1 citation

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