About this Research Topic

Background

Chronic kidney disease (CKD) affects more than 850 million people worldwide with rising incidence in low-resource settings. Several reports show that people living with CKD in low-resource settings do not have adequate access to modalities of kidney replacement therapies (KRT; including hemodialysis, peritoneal dialysis, and kidney transplantation). Although this makes early CKD detection strategies an important preventive measure for CKD in these settings, decisions on whether to screen for CKD or not remain contentious in nephrology. It remains unclear if population-wide early detection programs have value in low-resource settings given the relatively younger population affected by CKD and prevalent weak health systems. Challenges to early detection relate to priority setting in the context of prevalent health systems and political/social dynamics, availability of strategies that guarantee optimal utilization of limited human and material resources and ensuring appropriate return on investment following this process.

As part of our journal’s mission to address key aspects of nephrology, Frontiers in Nephrology is organizing a collection of articles focused on the Research topic “Chronic kidney disease: Reducing risk and preventing complications”. The Journal welcomes submissions of critical reviews, “pro” and “con” debates, and original epidemiological research within this area reporting on incidence/prevalence of CKD through early detection programs. Our aim is to enhance the literature to improve strategies for better detection and control of CKD, especially in resource-limited settings.

Examples of topics that will fall within the scope of this collection (but not limited to) include:

o Reports on clinical studies on the risk and burden of CKD, prevalence from early detection programs.

o Studies on general screening programs and targeted screening programs and their outcomes

o Systematic/scoping reviews on regional CKD detection programs and outcomes

o Studies on cost evaluations of early detection programs for CKD markers

o Studies on the burden of traditional and non-traditional CKD risk factors from early detection programs

o Reviews on early detection strategies (pitfalls, challenges, opportunities, etc.)

o Real life studies on the uptake of CKD management interventions (lifestyle, medications including RAASi, SGLT2i, statins)

o Studies on cardiovascular risk reduction in people living with CKD.

o Ethical issues related to early screening programs in low-resource settings.

Keywords: chronic kidney disease, CKD, prevention, reduction, nephrology, kidney

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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