Organ-Sparing Surgery for Genitourinary Cancers

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Background

Genitourinary cancers, such as renal cancer, bladder cancer, prostate cancer, penile cancer, and testicular cancer, are a series of common diseases that causes major health problems worldwide. Surgery is core to the management of these cancers. Although radical resection surgery is often recommended for advanced cancers, organ-sparing surgery is receiving increasing attention due to better preservation of normal tissues and organ function. For example, previous studies reported the treatment of renal cancer at the T2 stage by partial nephrectomy, as well as the treatment of prostate cancer by partial prostatectomy or focal therapy. In addition, the neoadjuvant therapy and adjuvant therapy for such organ-sparing surgery need to be further investigated and discussed. The purpose of this topic is to provide up-to-date reviews and original articles that highlight work in organ-sparing surgery for the treatment of genitourinary cancers and relevant neoadjuvant and adjuvant therapy, which we hope will not only integrate our current understanding but crystallize nascent questions that will help move the field forward.

Compared with radical resection surgery, the safety and treatment efficacy of organ-sparing surgery for genitourinary cancers, especially for advanced cancers, remains unclear. Besides, the neoadjuvant therapy and adjuvant therapy for such organ-sparing surgery need to be further addressed. The Research Topic aims to inspire novel insights into organ-sparing surgery for the treatment of genitourinary cancers, especially advanced cancers. We welcome Original Research articles, Review articles, Mini Reviews, Case Reports, Clinical Trials, and Perspectives that address the experience and process of organ-sparing surgery, as well as the relevant neoadjuvant and adjuvant therapy for the improvement of cancer management. We welcome submissions covering but not limited to the following sub-topics:

1) Organ-sparing surgery for the treatment of muscle invasive bladder cancer and relevant adjuvant therapy
2) Partial prostatectomy for the treatment of prostate cancer and relevant adjuvant therapy
3) Partial nephrectomy for the treatment of renal cancer over T2 stage and relevant adjuvant therapy
4) Partial adrenalectomy and relevant adjuvant therapy
5) Partial orchiectomy and relevant adjuvant therapy
6) Partial amputation of the penis and relevant adjuvant therapy
7) Focal therapy for genitourinary cancers
8) Salvage surgery for genitourinary cancers

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

All other Guest Editors declare no competing interests with regards to the Research Topic subject.

Keywords: genitourinary cancers, organ-sparing surgery, focal therapy, neoadjuvant therapy, salvage surgery

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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